Principles of operation of a DNP prepolarizer coupled to a rodent MRI scanner

被引:33
作者
Comment, A. [1 ]
van den Brandt, B. [2 ]
Uffmann, K. [3 ]
Kurdzesau, F. [1 ,2 ]
Jannin, S. [1 ]
Konter, J. A. [2 ]
Hautle, P. [2 ]
Wenckebach, W. T. [1 ]
Gruetter, R. [3 ]
van der Klink, J. J. [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Lab Phys Nanostruct Mat, CH-1015 Lausanne, Switzerland
[2] Paul Scherrer Inst, Villigen, Switzerland
[3] Ecole Polytech Fed Lausanne, Lab Funct & Metab Imaging, CH-1015 Lausanne, Switzerland
基金
瑞士国家科学基金会;
关键词
D O I
10.1007/s00723-008-0119-3
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 [原子与分子物理]; 070304 [物理化学]; 081704 [应用化学]; 1406 [纳米科学与工程];
摘要
A dynamic nuclear polarization prepolarizer was developed and coupled to a 9.4 T rodent magnetic resonance imaging scanner in order to perform in vivo hyperpolarization experiments. In the present paper, emphasis is put on methods and hardware performance rather than on in vivo results obtained with this setup. An overview of the main hardware components is given. The full procedure starting from the sample preparation and solid-state polarization to in vivo infusion is described.
引用
收藏
页码:313 / 319
页数:7
相关论文
共 4 条
[1]
CYTOTOXICITY OF COMMONLY USED NITROXIDE RADICAL SPIN PROBES [J].
ANKEL, EG ;
LAI, CS ;
HOPWOOD, LE ;
ZIVKOVIC, Z .
LIFE SCIENCES, 1987, 40 (05) :495-498
[2]
Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR [J].
Ardenkjaer-Larsen, JH ;
Fridlund, B ;
Gram, A ;
Hansson, G ;
Hansson, L ;
Lerche, MH ;
Servin, R ;
Thaning, M ;
Golman, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10158-10163
[3]
Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner [J].
Comment, A. ;
van den Brandt, B. ;
Uffmann, K. ;
Kurdzesau, F. ;
Jannin, S. ;
Konter, J. A. ;
Hautle, P. ;
Wenckebach, W. TH. ;
Gruetter, R. ;
van der Klink, J. J. .
CONCEPTS IN MAGNETIC RESONANCE PART B-MAGNETIC RESONANCE ENGINEERING, 2007, 31B (04) :255-269
[4]
Conradi M.S., 1993, CONCEPT MAGNETIC RES, V5, P243