Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

被引：41

作者：

Aanaes, Kasper ^{[1
]}

Rickelt, Lars Fledelius ^{[2
]}

Johansen, Helle Krogh ^{[3
]}

von Buchwald, Christian ^{[1
]}

Pressler, Tacjana ^{[4
]}

Hoiby, Niels ^{[3
]}

Jensen, Peter Ostrup ^{[3
]}

机构：

[1] Univ Copenhagen Hosp, Dept Otolaryngol Head & Neck Surg, Rigshosp, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Marine Biol Lab, Dept Biol, DK-3000 Helsingor, Denmark

[3] Rigshosp, Dept Clin Microbiol, DK-2100 Copenhagen, Denmark

[4] Rigshosp, Copenhagen CF Ctr, Pediat Pulm Serv, Dept Pediat, DK-2100 Copenhagen, Denmark

来源：

JOURNAL OF CYSTIC FIBROSIS | 2011年 / 10卷 / 02期

关键词：

Pseudomonas aeruginosa; Cystic fibrosis; Maxillary sinuses; Oxygen tension; Sinus surgery; Catheter optode; PSEUDOMONAS-AERUGINOSA; LUNG INFECTION; BIOFILMS; DISEASE;

D O I：

10.1016/j.jcf.2010.12.002

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Pseudomonas aeruginosa in the sinuses plays a role in the lungs in cystic fibrosis (CF) patients, but little is known about the sinus environment where the bacteria adapt. Anoxic areas are found in the lower respiratory airways but it is unknown if the same conditions exist in the sinuses. Methods: The oxygen tension (pO(2)) was measured, using a novel in vivo method, in the maxillary sinus in a group of 20 CF patients. Results: The CF patients had a significant lower pO(2) on the mucosa but not in the sinus lumen as compared with a control group of non-CF patients. Anoxic conditions were found in 7/39 (18%) of the sinuses from where we cultured P. aeruginosa, Stenotrophomonas maltophilia and/or coagulase negative staphylococci. Conclusion: These findings support our hypothesis that P. aeruginosa can adapt or acclimate to the environment in the lungs, during growth in anoxic parts of the paranasal sinuses. (C) 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：114 / 120

页数：7

共 27 条

[1]

AUST R, 1994, ACTA OTO-LARYNGOL, P7

[2] OXYGEN-TENSION IN HUMAN MAXILLARY SINUS UNDER NORMAL AND PATHOLOGICAL CONDITIONS [J].

AUST, R ;

DRETTNER, B .

ACTA OTO-LARYNGOLOGICA, 1974, 78 (3-4) :264-269

[3] Pseudomonas aeruginosa Biofilms in the Respiratory Tract of Cystic Fibrosis Patients [J].

Bjarnsholt, Thomas ;

Jensen, Peter Ostrup ;

Fiandaca, Mark J. ;

Pedersen, Jette ;

Hansen, Christine Ronne ;

Andersen, Claus Bogelund ;

Pressler, Tacjana ;

Givskov, Michael ;

Hoiby, Niels .

PEDIATRIC PULMONOLOGY, 2009, 44 (06) :547-558

[4] PURULENT AND NON-PURULENT MAXILLARY SINUS SECRETIONS WITH RESPECT TO PO2, PCO2 AND PH [J].

CARENFELT, C ;

LUNDBERG, C .

ACTA OTO-LARYNGOLOGICA, 1977, 84 (1-2) :138-144

[5] Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants [J].

Ciofu, Oana ;

Mandsberg, Lotte F. ;

Bjarnsholt, Thomas ;

Wassermann, Tina ;

Hoiby, Niels .

MICROBIOLOGY-SGM, 2010, 156 :1108-1119

[6] Role of Oxygen Availability in CFTR Expression and Function [J].

Guimbellot, Jennifer S. ;

Fortenberry, James A. ;

Siegal, Gene P. ;

Moore, Bryan ;

Wen, Hui ;

Venglarik, Charles ;

Chen, Yiu-Fai ;

Oparil, Suzanne ;

Sorscher, Eric J. ;

Hong, Jeong S. .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2008, 39 (05) :514-521

[7]

Gysin C, 2000, PEDIATR PULM, V30, P481, DOI 10.1002/1099-0496(200012)30:6<481::AID-PPUL8>3.0.CO

[8]

2-N

[9]

HANSEN SK, 2009, 12 INT C HAN GERM AU

[10] Pulmonary TH2 response in Pseudomonas aeruginos-infected patients with cystic fibrosis [J].

Hartl, D ;

Griese, M ;

Kappler, M ;

Zissel, G ;

Reinhardt, D ;

Rebhan, C ;

Schendel, DJ ;

Krauss-Etschmann, S .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (01) :204-211

← 1 2 3 →