Nanoparticles in medicine: Therapeutic applications and developments

被引：1846

作者：

Zhang, L. ^{[2
,3
]}

Gu, F. X. ^{[2
,3
]}

Chan, J. M. ^{[4
]}

Wang, A. Z. ^{[1
,5
]}

Langer, R. S. ^{[2
,3
]}

Farokhzad, O. C. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesiol,Lab Nanomed & Biomat, Boston, MA 02115 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[3] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[4] MIT, Dept Biol, Cambridge, MA USA

[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiat Oncol, Boston, MA 02115 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2008年 / 83卷 / 05期

关键词：

D O I：

10.1038/sj.clpt.6100400

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanotechnology is the understanding and control of matter generally in the 1-100 nm dimension range. The application of nanotechnology to medicine, known as nanomedicine, concerns the use of precisely engineered materials at this length scale to develop novel therapeutic and diagnostic modalities.(1,2) Nanomaterials have unique physicochemical properties, such as ultra small size, large surface area to mass ratio, and high reactivity, which are different from bulk materials of the same composition. These properties can be used to overcome some of the limitations found in traditional therapeutic and diagnostic agents.

引用

页码：761 / 769

页数：9

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