Resolved: Normal glomeruli filter nephrotic levels of albumin

被引：67

作者：

Comper, Wayne D.

Haraldsson, Borje ^{[1
]}

Deen, William M. ^{[2
]}

机构：

[1] Univ Gothenburg, Inst Med, Dept Mol & Clin Med Nephrol, Gothenburg, Sweden

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 03期

关键词：

D O I：

10.1681/ASN.2007090997

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The glomerular filtration barrier has long been thought largely impermeable to albumin. Startling new data suggest it may not be especially important in this process. Much of the argument hinges on whether charge selectivity really exists, how feasible it is for enormous quantities of albumin to instead be reclaimed by the proximal tubule, and the technical merits of previous experiments. Three experts in the field debate the merits of this argument.

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收藏

页码：427 / 432

页数：6

相关论文

共 49 条

[1] Increased glomerular permeability to negatively charged Ficoll relative to neutral Ficoll in rats [J].

Asgeirsson, Daniel ;

Venturoli, Daniele ;

Rippe, Bengt ;

Rippe, Catarina .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2006, 291 (05) :F1083-F1089

[2] Increased glomerular albumin permeability in old spontaneously hypertensive rats [J].

Bakoush, O ;

Tencer, J ;

Torffvit, O ;

Tenstad, O ;

Skogvall, I ;

Rippe, B .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2004, 19 (07) :1724-1731

[3] GLOMERULAR SIEVING OF ANIONIC AND NEUTRAL BOVINE ALBUMINS IN PROTEINURIC RATS [J].

BERTOLATUS, JA ;

HUNSICKER, LG .

KIDNEY INTERNATIONAL, 1985, 28 (03) :467-476

[4] Renal albumin absorption in physiology and pathology [J].

Birn, H ;

Christensen, E .

KIDNEY INTERNATIONAL, 2006, 69 (03) :440-449

[5] PERMSELECTIVITY OF GLOMERULAR CAPILLARY WALL .3. RESTRICTED TRANSPORT OF POLYANIONS [J].

CHANG, RLS ;

DEEN, WM ;

ROBERTSON, CR ;

BRENNER, BM .

KIDNEY INTERNATIONAL, 1975, 8 (04) :212-218

[6] PERMSELECTIVITY OF GLOMERULAR CAPILLARY WALL TO MACROMOLECULES .2. EXPERIMENTAL STUDIES IN RATS USING NEUTRAL DEXTRAN [J].

CHANG, RLS ;

UEKI, IF ;

TROY, JL ;

DEEN, WM ;

ROBERTSON, CR ;

BRENNER, BM .

BIOPHYSICAL JOURNAL, 1975, 15 (09) :887-906

[7] Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule [J].

Christensen, EI ;

Birn, H .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 280 (04) :F562-F573

[8] Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules [J].

Christensen, EI ;

Devuyst, O ;

Dom, G ;

Nielsen, R ;

Van Der Smissen, P ;

Verroust, P ;

Leruth, M ;

Guggino, WB ;

Courtoy, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8472-8477

[9] Urinary clearance of albumin is critically determined by its tertiary structure [J].

Clavant, SP ;

Comper, WD .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2003, 142 (06) :372-384

[10] Albumin fragments in normal rat urine are derived from rapidly degraded filtered albumin [J].

Clavant, SP ;

Greive, KA ;

Nikolovski, J ;

Reeve, S ;

Smith, AI ;

Comper, WD .

NEPHROLOGY, 2003, 8 (02) :72-79

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