Executive Functions, Information Sampling, and Decision Making in Narcolepsy With Cataplexy

被引:40
作者
Delazer, Margarete [1 ]
Hoegl, Birgit [1 ]
Zamarian, Laura [1 ]
Wenter, Johanna
Gschliesser, Viola [1 ]
Ehrmann, Laura [1 ]
Brandauer, Elisabeth [1 ]
Cevikkol, Zebra [1 ]
Frauscher, Birgit [1 ]
机构
[1] Innsbruck Med Univ, Dept Clin Neurol, Innsbruck, Austria
关键词
decision making; reward processing; executive functions; IST; IED; OTS; VENTROMEDIAL PREFRONTAL CORTEX; VENTRAL TEGMENTAL AREA; PARKINSONS-DISEASE; COGNITIVE DEFICITS; REWARD-SEEKING; WORKING-MEMORY; AMYGDALA; DOPAMINE; RISK; DYSFUNCTION;
D O I
10.1037/a0022357
中图分类号
B849 [应用心理学];
学科分类号
040203 [应用心理学];
摘要
Objective: Narcolepsy with cataplexy (NC) affects neurotransmitter systems regulating emotions and cognitive functions. This study aimed to assess executive functions, information sampling, reward processing, and decision making in NC. Method: Twenty-one NC patients and 58 healthy participants performed an extensive neuropsychological test battery. Results: NC patients scored as controls in executive function tasks assessing set shifting, reversal learning, working memory, and planning. Group differences appeared in a task measuring information sampling and reward sensitivity. NC patients gathered less information, tolerated a higher level of uncertainty, and were less influenced by reward contingencies than controls. NC patients also showed reduced learning in decision making and had significantly lower scores than controls in the fifth block of the IOWA gambling task. No correlations were found with measures of sleepiness. Conclusions: NC patients may achieve high performance in several neuropsychological domains, including executive functions. Specific differences between NC patients and controls highlight the importance of the hypocretin system in reward processing and decision making and are in line with previous neuroimaging and neurophysiological studies.
引用
收藏
页码:477 / 487
页数:11
相关论文
共 73 条
[1]
Neural substrates of awakening probed with optogenetic control of hypocretin neurons [J].
Adamantidis, Antoine R. ;
Zhang, Feng ;
Aravanis, Alexander M. ;
Deisseroth, Karl ;
De Lecea, Luis .
NATURE, 2007, 450 (7168) :420-U9
[2]
DOES MEMORY IMPAIRMENT EXIST IN NARCOLEPSY-CATAPLEXY [J].
AGUIRRE, M ;
BROUGHTON, R ;
STUSS, D .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1985, 7 (01) :14-24
[3]
[Anonymous], 2000, WMS R WECHSLER GEDAC
[4]
Aschenbrenner S, 2002, REGENSBURGER WORTFLU
[5]
Risk assessment in man and mouse [J].
Balci, Fuat ;
Freestone, David ;
Gallistel, Charles R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (07) :2459-2463
[6]
Hypocretins (orexins) and sleep-wake disorders [J].
Baumann, CR ;
Bassetti, CL .
LANCET NEUROLOGY, 2005, 4 (10) :673-682
[7]
Emotion, decision making and the orbitofrontal cortex [J].
Bechara, A ;
Damasio, H ;
Damasio, AR .
CEREBRAL CORTEX, 2000, 10 (03) :295-307
[8]
Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions [J].
Bechara, A ;
Tranel, D ;
Damasio, H .
BRAIN, 2000, 123 :2189-2202
[9]
Bechara A, 1998, J NEUROSCI, V18, P428
[10]
Role of the amygdala in decision-making [J].
Bechara, A ;
Damasio, H ;
Damasio, AR .
AMYGDALA IN BRAIN FUNCTION: BASIC AND CLINICAL APPROACHES, 2003, 985 :356-369