A cost comparison of infertility treatment for clomiphene resistant polycystic ovary syndrome

被引:10
作者
Fridström, M
Sjöblom, P
Granberg, M
Hillensjö, T
机构
[1] Huddinge Univ Hosp, IVF Unit, Huddinge, Sweden
[2] Scandinavian IVF Sci AB, Gothenburg, Sweden
[3] Carlanderska Sjukhemmet, Fertil Ctr, Gothenburg, Sweden
关键词
cost effectiveness; fertilization in vitro; infertility treatment; ovulation induction; polycystic ovary syndrome (PCOS);
D O I
10.1034/j.1600-0412.1999.780308.x
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
Background The study compares treatment outcome and casts of ovulation induction cycles and in vitro fertilization cycles in infertile women with clomiphene resistant polycystic ovary syndrome. Methods. Twenty-eight infertile women with clomiphene resistant polycystic ovary syndrome referred to a university clinic were prospectively randomized to ovulation induction or in vitro fertilization. Forty-one ovulation induction cycles and thirty in vitro fertilization cycles were performed. Mann-Whitney U-test Mras used for between group comparisons and frequencies were compared with Fisher's exact test. Results. More pregnancies per completed cycle were noted in the in vitro fertilization group than in the ovulation induction group. Drug costs were not much higher in the in vitro fertilization group but treatment costs were higher due to the additional costs of ovum pick up and embryo transfer. The cost per pregnancy was about twice as high in the ovulation induction group as in the in vitro fertilization group. The cost per term pregnancy including delivery was 1.6 times higher in the ovulation induction group. Conclusion. For a group of obese women with clomiphene resistant polycystic ovary syndrome, in vitro fertilization seems a cost-effective treatment.
引用
收藏
页码:212 / 216
页数:5
相关论文
共 28 条
[1]
Arey LB, 1939, AM J OBSTET GYNECOL, V37, P12
[2]
PREVALENCE OF OLIGOMENORRHEA AND AMENORRHEA IN A COLLEGE POPULATION [J].
BACHMANN, GA ;
KEMMANN, E .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1982, 144 (01) :98-102
[3]
MISCARRIAGE RATES FOLLOWING INVITRO FERTILIZATION ARE INCREASED IN WOMEN WITH POLYCYSTIC OVARIES AND REDUCED BY PITUITARY DESENSITIZATION WITH BUSERELIN [J].
BALEN, AH ;
TAN, SL ;
MACDOUGALL, J ;
JACOBS, HS .
HUMAN REPRODUCTION, 1993, 8 (06) :959-964
[4]
Bergh C, 1998, ACTA OBSTET GYN SCAN, V77, P68
[5]
LENGTH AND VARIABILITY OF HUMAN MENSTRUAL CYCLE [J].
CHIAZZE, L ;
BRAYER, FT ;
MACISCO, JJ ;
PARKER, MP ;
DUFFY, BJ .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1968, 203 (06) :377-&
[6]
WEIGHT-LOSS RESULTS IN SIGNIFICANT IMPROVEMENT IN PREGNANCY AND OVULATION RATES IN ANOVULATORY OBESE WOMEN [J].
CLARK, AM ;
LEDGER, W ;
GALLETLY, C ;
TOMLINSON, L ;
BLANEY, F ;
WANG, X ;
NORMAN, RJ .
HUMAN REPRODUCTION, 1995, 10 (10) :2705-2712
[7]
HETEROGENEITY OF THE POLYCYSTIC OVARY SYNDROME - CLINICAL, ENDOCRINE AND ULTRASOUND FEATURES IN 556 PATIENTS [J].
CONWAY, GS ;
HONOUR, JW ;
JACOBS, HS .
CLINICAL ENDOCRINOLOGY, 1989, 30 (04) :459-470
[8]
OVULATION INDUCTION WITH LOW-DOSE FOLLICLE-STIMULATING-HORMONE IN WOMEN WITH THE POLYCYSTIC-OVARY-SYNDROME [J].
DALE, PO ;
TANBO, T ;
LUNDE, O ;
ABYHOLM, T .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1993, 72 (01) :43-46
[9]
INVITRO FERTILIZATION IN INFERTILE WOMEN WITH THE POLYCYSTIC OVARIAN SYNDROME [J].
DALE, PO ;
TANBO, T ;
ABYHOLM, T .
HUMAN REPRODUCTION, 1991, 6 (02) :238-241
[10]
MEDICAL PROGRESS - POLYCYSTIC-OVARY-SYNDROME [J].
FRANKS, S .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (13) :853-861