Facile chemical modification of the poly(L-histidine) for a new pH-sensitive polypeptide

被引：6

作者：

Asayama, S ^{[1
]}

Kawakami, H ^{[1
]}

Nagaoka, S ^{[1
]}

机构：

[1] Tokyo Metropolitan Univ, Dept Appl Chem, Hachioji, Tokyo 1920397, Japan

来源：

CHEMISTRY LETTERS | 2003年 / 32卷 / 12期

关键词：

D O I：

10.1246/cl.2003.1152

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have synthesized the Poly(L-histidine) (PLH) with aliphatic primary amino groups for conjugation as a new pH-sensitive polypeptide. The resulting aminated PLH suddenly precipitated out of the aqueous medium above pH 6.0 owing to the deprotonation of imidazole groups. The aminated PLH was successfully conjugated with maltopentaose by reductive amination. The resulting PLH-maltopentaose conjugate improved its water solubility at physiological pH.

引用

页码：1152 / 1153

页数：2

共 6 条

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