The main function of IL-2 is to promote the development of T regulatory cells

被引：261

作者：

Malek, TR ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2003年 / 74卷 / 06期

关键词：

CD4(+) CD25(+); autoimmunity; IL-2;

D O I：

10.1189/jlb.0603272

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Based primarily on vitro studies, interleukin (IL)-2 has been considered a key growth and death factor for antigen-activated T lymphocytes. IL-2 is also essential to maintain self-tolerance, as IL-2- and IL-2 receptor-deficient mice exhibit lethal autoimmunity. The intrinsic death-sensitizing activity of IL-2 was thought to be a key mediator for apoptosis of peripheral autoreactive T cells. However, recent in vivo studies strongly favor a model whereby IL-2 controls autoimmmtity through the production of CD4(+)CD25(+) T regulatory (Treg) cells. In this setting, IL-2 is essential for expansion of Treg cells within the thymus and in peripheral neonatal-immune tissue. Thus, from being considered the primary growth factor for antigen-activated T lymphocytes, these new findings redefine the pivotal role for IL-2 as the major inducer for the developmental production of suppressive Treg cells. J. Leukoc. Biol. 74: 961-965; 2003.

引用

页码：961 / 965

页数：5

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