Development of a tissue-engineered bypass graft seeded with stem cells

被引：23

作者：

DiMuzio, Paul ^{[1
]}

Fischer, Lauren ^{[1
]}

McIlhenny, Stephen ^{[1
]}

DiMatteo, Christopher ^{[1
]}

Golesorhki, Negar ^{[1
]}

Grabo, Daniel ^{[1
]}

Tarola, Nicholas ^{[1
]}

Mericli, Alexander ^{[1
]}

Shapiro, Irving ^{[2
]}

Tulenko, Thomas ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Orthoped Surg Res, Philadelphia, PA 19107 USA

来源：

VASCULAR | 2006年 / 14卷 / 06期

基金：

美国国家卫生研究院;

关键词：

tissue engineering; vascular graft; adult stem cells;

D O I：

10.2310/6670.2006.00058

中图分类号：

R6 [外科学];

学科分类号：

1002 [临床医学]; 100210 [外科学];

摘要：

The gold standard conduit for bypass of diseased small-diameter arteries remains autologous vascular tissue. In the absence of such tissue, patients are offered bypass with prosthetic material, with far less durable results. Vascular tissue engineering, the creation of a vascular conduit by seeding a tubular scaffold with various cells, may offer an alternative approach to this difficult situation. Herein we review some of the significant challenges that remain in designing an ideal vascular conduit and outline potential solutions offered by a graft created by seeding natural vascular tissue (decellularized vein allograft) with readily available autologous cells (adipose-derived stem cells).

引用

页码：338 / 342

页数：5

共 22 条

[1]

Contaminants from the transplant contribute to intimal hyperplasia associated with microvascular endothelial cell seeding [J].