Exosomes: roles and therapeutic potential in osteoarthritis

被引：203

作者：

Ni, Zhenhong ^{[1
]}

Zhou, Siru ^{[2
]}

Li, Song ^{[1
,3
]}

Kuang, Liang ^{[1
]}

Chen, Hangang ^{[1
]}

Luo, Xiaoqing ^{[1
]}

Ouyang, Junjie ^{[1
]}

He, Mei ^{[1
]}

Du, Xiaolan ^{[1
]}

Chen, Lin ^{[1
]}

机构：

[1] Army Med Univ, State Key Lab Trauma Burns & Combined Injury, Dept Wound Repair & Rehabil Med,Res Inst Surg, Ctr Bone Metab & Repair,Daping Hosp,Lab Prevent &, Chongqing, Peoples R China

[2] Army Med Univ PLA, Daping Hosp, State Key Lab Trauma Burns & Combined Injury, Med Cformat H Type Vessel Subchondral Enter Traum, Chongqing, Peoples R China

[3] Army Med Univ, Sch Basic Med Sci, Eleven Squadron Three Brigade, Chongqing, Peoples R China

来源：

BONE RESEARCH | 2020年 / 8卷 / 01期

基金：

中国国家自然科学基金;

关键词：

MESENCHYMAL STEM-CELLS; INFRAPATELLAR FAT PAD; GLUCOCORTICOID-INDUCED OSTEONECROSIS; CRUCIATE LIGAMENT INTEGRITY; SUBCHONDRAL BONE; KNEE OSTEOARTHRITIS; ARTICULAR-CARTILAGE; EXTRACELLULAR VESICLES; FEMORAL-HEAD; INTRAARTICULAR INJECTION;

D O I：

10.1038/s41413-020-0100-9

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Exosomes participate in many physiological and pathological processes by regulating cell-cell communication, which are involved in numerous diseases, including osteoarthritis (OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling. This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.

引用

页数：18

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