Enantiocontrolled synthesis of spirooxindoles based on the [5+2] cycloaddition of a Tp(CO)2Mo(pyridinyl) scaffold (Tp = hydridotrispyrazolylborate)

被引：67

作者：

Malinakova, HC ^{[1
]}

Liebeskind, LS ^{[1
]}

机构：

[1] Emory Univ, Sanford S Atwood Chem Ctr, Atlanta, GA 30322 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol000313z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A [5 + 2] cycloaddition of the pyridinyl pi -complex (-)-1 (98% ee) to methyleneoxindole 2 afforded the spirooxindole complex (-)-3 in high enantiomeric purity. Complex (-)-3 was converted to pyrrolidine (-)-8 (97% ee), which is related to potent cytotoxic analogues of the spirotryprostatins alkaloids.

引用

页码：4083 / 4086

页数：4

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