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Lipid rafts and their roles in T-cell activation

被引：39
作者：
Horejsí, V [1 ]
机构：
[1] Acad Sci Czech Republ, Inst Mol Genet, CR-14220 Prague, Czech Republic
来源：
MICROBES AND INFECTION | 2005年 / 7卷 / 02期
关键词：
lipid rafts; T-cell; immunoreceptor signaling;
D O I：
10.1016/j.micinf.2004.12.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lipid rafts are defined as detergent-resistant membrane microdomains of specific lipid and protein composition. They are involved in many aspects of cell biology, including T-cell activation and immunoreceptor signaling. This review discusses current controversies around lipid rafts and summarizes recent developments in the area. (c) 2005 Elsevier SAS. All rights reserved.
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页码：310 / 316
页数：7
相关论文
共 61 条
  • [1] CD8β endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56lck complexes
    Arcaro, A
    Grégoire, C
    Bakker, TR
    Baldi, L
    Jordan, M
    Goffin, L
    Boucheron, N
    Wurm, F
    van der Merwe, PA
    Malissen, B
    Luescher, IF
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (10) : 1485 - 1495
  • [2] Measles virus interacts with and alters signal transduction in T-cell lipid rafts
    Avota, E
    Müller, N
    Klett, M
    Schneider-Schaulies, S
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (17) : 9552 - 9559
  • [3] Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells
    Balamuth, F
    Leitenberg, D
    Unternaehrer, J
    Mellman, I
    Bottomly, K
    [J]. IMMUNITY, 2001, 15 (05) : 729 - 738
  • [4] Membrane lipid microdomains and the role of PKCθ in T cell activation
    Bi, K
    Altman, A
    [J]. SEMINARS IN IMMUNOLOGY, 2001, 13 (02) : 139 - 146
  • [5] Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation
    Brdicka, T
    Pavilstová, D
    Leo, A
    Bruyns, E
    Korínek, V
    Angelisová, P
    Scherer, J
    Shevchenko, A
    Shevchenko, A
    Hilgert, I
    Cerny, J
    Drbal, K
    Kuramitsu, Y
    Kornacker, B
    Horejsí, V
    Schraven, B
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (09) : 1591 - 1604
  • [6] LIME:: A new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling
    Brdicková, N
    Brdicka, T
    Angelisová, P
    Horváth, O
    Spicka, J
    Hilgert, I
    Paces, J
    Simeoni, L
    Kliche, S
    Merten, C
    Schraven, B
    Horejsí, V
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (10) : 1453 - 1462
  • [7] Structure and function of sphingolipid- and cholesterol-rich membrane rafts
    Brown, DA
    London, E
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) : 17221 - 17224
  • [8] Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts
    Claas, C
    Stipp, CS
    Hemler, ME
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) : 7974 - 7984
  • [9] Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation
    Darlington, PJ
    Baroja, ML
    Chau, TA
    Siu, E
    Ling, V
    Carreno, BM
    Madrenas, J
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (10) : 1337 - 1347
  • [10] CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection
    Delgado, P
    Fernández, E
    Dave, V
    Kappes, D
    Alarcón, B
    [J]. NATURE, 2000, 406 (6794) : 426 - 430
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