Steroidal saponins from the rhizomes of Hosta sieboldii and their cytostatic activity on HL-60 cells

被引：63

作者：

Mimaki, Y ^{[1
]}

Kuroda, M ^{[1
]}

Kameyama, A ^{[1
]}

Yokosuka, A ^{[1
]}

Sashida, Y ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 48卷 / 08期

关键词：

Hosta sieboldii; Liliaceae; rhizomes; steroidal saponins; spirostanol saponins; furostanol saponins; cytostatic activity; HL-60; cells;

D O I：

10.1016/S0031-9422(98)00157-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

total of eighteen steroidal saponins were isolated from the rhizomes of Hosta sieboldii, one of which appeared to be the first isolation from a plant source and six to be new compounds. The structures of the new saponins were determined by spectral data and a few chemical transformations to be (25R)-2 alpha,3 beta-dihydroxy-5 alpha-spirostan-12-one (manogenin) 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-beta-D-glucopyranosyl-(l-->4)-beta-D-galacltopyranoside}, (25R)-2 alpha,3 beta-dihydroxy-5 alpha-spirost-9-en-12-one (9,11-dehydromanogenin) 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside}, 9,11-dehydromanogenin 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-[O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-xylopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside}, (25R)-2 alpha,3 beta-dihydroxy-26-beta-D-glucopyranosyloxy-22-methoxy-5 alpha-furostan-12-one 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside}, (25R)-2 alpha,3 beta-dihydroxy-26-beta-D-glucopyranosyloxy-22-methoxy-5 alpha-furost-9-en-12-one 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside} and (25R)-5 alpha-spirostan-2 alpha,3 beta,12 beta-triol 3-O-(O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-galactopyranoside), respectively. Cytostatic activity of the isolated saponins on leukaemia HL-60 cells was examined. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1361 / 1369

页数：9

共 16 条

[1]

C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].