Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population

被引：18

作者：

Kyogoku, Chieko ^{[1
]}

Yanagi, Masaya ^{[2
]}

Nishimura, Kunihiro ^{[3
]}

Sugiyama, Daisuke ^{[3
]}

Morinobu, Akio

Fukutake, Masaaki ^{[2
]}

Maeda, Kiyoshi ^{[2
]}

Shirakawa, Osamu ^{[4
]}

Kuno, Takayoshi ^{[5
]}

Kumagai, Shunichi

机构：

[1] Kobe Univ, Grad Sch Med, Dept Clin Pathol & Immunol, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Grad Sch Med, Dept Psychiat, Kobe, Hyogo 6500017, Japan

[3] Kobe Univ, Grad Sch Med, Dept Evidence Based Lab Med, Kobe, Hyogo 6500017, Japan

[4] Kinki Univ, Sch Med, Dept Neuropsychiat, Osaka 589, Japan

[5] Kobe Univ, Grad Sch Med, Dept Biochem & Mol Biol, Div Mol Pharmacol & Pharmacogenom, Kobe, Hyogo 6500017, Japan

来源：

PSYCHIATRY RESEARCH | 2011年 / 185卷 / 1-2期

关键词：

Schizophrenia; Calcineurin A gamma subunit (PPP3CC); Early growth response 3 (EGR3); CANDIDATE GENES; NO ASSOCIATION; PLASTICITY; DOPAMINE; SUPPORT; LOCI;

D O I：

10.1016/j.psychres.2009.11.003

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

To examine the association of PPP3CC (rs10108011 and rs2461491) and EGR3 (rs3750192) single-nucleotide polymorphisms (SNPs) with Japanese schizophrenia, we performed a case-control association study using 337 patients and 369 healthy controls. As a result, by our moderated cohort-size study, PPP3CC and EGR3 are not genetic risk factors for schizophrenia, whereas meta-analysis showed weak association of rs10108011 with schizophrenia in the Japanese population (odds ratio (OR) = 1.12, P = 0.01). (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：16 / 19

页数：4

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