Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme

被引：113

作者：

Tor, Y ^{[1
]}

Hermann, T

Westhof, E

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] CNRS, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1074-5521(98)90286-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aminoglycoside antibiotics inhibit protein biosynthesis and various ribozymes. Structural electrostatic complementarity can explain the inhibition mechanism of the hammerhead ribozyme: positively charged ammonium groups match the negatively charged metal-ion-binding pockets created by the RNA fold's electrostatic field.

引用

页码：R277 / R283

页数：7

共 41 条

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