Remote control over guidance and release properties of composite polyelectrolyte based capsules

被引：136

作者：

Antipina, Maria N. ^{[2
]}

Sukhorukov, Gleb B. ^{[1
,2
]}

机构：

[1] Univ London, Sch Engn & Mat Sci, London, England

[2] ASTAR, Inst Mat Res & Engn, Singapore, Singapore

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2011年 / 63卷 / 09期

关键词：

Drug delivery; Polyelectrolyte capsules; Remotely controlled release; Ultrasound; Magnetic capsules; Light addressable capsules; RADIOFREQUENCY ABLATION; MAGNETIC NANOPARTICLES; POLYMER MICROCAPSULES; MULTILAYER CAPSULES; THERMAL-DESTRUCTION; GOLD NANOPARTICLES; DRUG; LIPOSOMES; PARTICLES; SHELL;

D O I：

10.1016/j.addr.2011.03.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polyelectrolyte multilayer capsules represent a unique tool to fabricate micron- and submicron-sized delivery systems with the properties of external guidance by means of remote physical influence. Embedding of nanoparticles into polyelectrolyte multilayer constructs opens up the opportunities to navigate the capsules with magnetic field and in-situ trigger the release of encapsulated material in response to the physical stimuli, such as light and ultrasound. So far, optically- and magnetically-induced addressing of the polyelectrolyte multilayer capsules internalized by the living cells in-vitro has been demonstrated. In this review, we discuss the state of the art, future perspectives and anticipated obstacles of in-vivo and in-vitro applications of the polyelectrolyte capsules performing remotely controlled release delivery of bioactives. Crown Copyright (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：716 / 729

页数：14

共 80 条

[1] Combined radiofrequency ablation and adjuvant liposomal chemotherapy: Effect of chemotherapeutic agent, nanoparticle size, and circulation time [J].