Traditional Chinese drug ShuXueTong facilitates angiogenesis during wound healing following traumatic brain injury

被引：52

作者：

Jin, Xiaoying ^{[1
]}

Shen, Gang ^{[2
]}

Gao, Feng ^{[2
]}

Zheng, Xuesheng ^{[2
]}

Xu, Xiaoyan ^{[2
]}

Shen, Fang ^{[2
]}

Li, Gu ^{[2
]}

Gong, Jiangbiao ^{[2
]}

Wen, Liang ^{[2
]}

Yang, Xiaofeng ^{[2
]}

Bie, Xiaodong ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Tradit Chinese Med, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurosurg, Hangzhou 310009, Zhejiang, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2008年 / 117卷 / 03期

关键词：

ShuXueTong; angiogenesis; traumatic brain injury;

D O I：

10.1016/j.jep.2008.02.033

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Ethnopharmacological relevance: ShuXueTong injection is a traditional Chinese drug designed to treat the patients of "blood stasis and stagnation (yu xue yu zhi)", including subacute brain trauma. However, the mechanism of the therapeutic effect of ShuXueTong on traumatic brain injury is unknown yet. Aim of the study: We hypothesized that ShuXueTong may promote the brain wound healing by facilitating angiogenesis. Thus this study was designed to explore this hypothesis. Materials and methods: By means of microvessel count, Western blotting, immunocytochemistry, methyl thiazolyl tetrazolium assay and etc., the effect of ShuXueTong on the angiogenesis of brain wound was studied and then its influence on the VEGF/VEGFR-2 pathway were explored. Results: ShuXueTong facilitates angiogenesis in the brain wound and improves the neurological function of the traumatized rats. VEGF expression in the lesion was elevated due to ShuXueTong induction. The in vitro experiment revealed VEGFR-2 and SRF expression in the endothelial cells were enhanced when exposed to ShuXueTong for merely 1 d. Moreover, ShuXueTong promoted the endothelial cell proliferation via the VEGF/VEGFR-2 pathway. Conclusions: The mechanism of the therapeutic effect of ShuXueTong on traumatic brain injury lies at least partly in the enhanced angiogenesis in the lesion. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：473 / 477

页数：5

共 20 条

[1]

Mechanisms of angiogenesis and arteriogenesis [J].