Palladium-catalyzed tandem Heck reaction/C-H functionalization - Preparation of spiro-indane-oxindoles

被引：167

作者：

Ruck, Rebecca T. ^{[1
]}

Huffman, Mark A. ^{[1
]}

Kim, Mary M. ^{[1
]}

Shevlin, Michael ^{[1
]}

Kandur, Wynne V. ^{[1
]}

Davies, Ian W. ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 25期

关键词：

C-H activation; Heck reaction; oxindoles; palladium;

D O I：

10.1002/anie.200800549

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Tied up nicely: A novel tandem reaction involving an intramolecular Heck reaction with subsequent functionalization of an unactivated C-H bond to generate spiro-fused indane-oxindoles is described (see scheme; PMB = p-methoxybenzyl). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4711 / 4714

页数：4

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