Is haemozoin a target for antimalarial drugs?

被引：29

作者：

Meshnick, SR

机构：

[1] Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI 48109-2029

来源：

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY | 1996年 / 90卷 / 04期

关键词：

D O I：

10.1080/00034983.1996.11813065

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Malarial parasites utilize a unique pathway to degrade haemoglobin. Most of the haem which is released during haemoglobin degradation is incorporated into haemozoin. The mechanism of haemozoin synthesis and the structure of haemozoin are controversial. Neither chloroquine nor artemisinin appear to affect haemozoin synthesis in vivo. Artemisinin is activated by intraparasitic haem and iron into a free radical which then alkylates specific malarial proteins.

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页码：367 / 372

页数：6

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