Leukocyte chemotactic factor 2: A novel renal amyloid protein

被引:122
作者
Benson, Merrill D. [1 ,2 ]
James, Sam [3 ]
Scott, Katherine [4 ]
Liepnieks, Juris J. [1 ]
Kluve-Beckerman, Barbara [1 ]
机构
[1] Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA
[2] Roudebush VA Med Ctr, Indianapolis, IN USA
[3] San Francisco Gen Hosp, Div Nephrol, San Francisco, CA 94110 USA
[4] Univ Arizona, Hlth Sci Ctr, Dept Pathol, Tucson, AZ USA
关键词
amyloid; kidney; nephrotic syndrome;
D O I
10.1038/ki.2008.152
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Renal amyloid deposits can often be seen in primary amyloidosis (immunoglobulin light chain disease) or in secondary forms such as reactive amyloidosis as well as in several hereditary forms where a variety of mutant proteins 'precipitate' as amyloid plaques. However, in rare cases, amyloidosis may be identified by renal biopsy, but no definitive diagnosis could be made. We have isolated amyloid fibrils from such a case in which the patient presented with nephrotic syndrome and subsequent azotemia requiring hemodialysis. Evaluation for amyloid deposition in other organ systems was negative and immunohistochemical analysis of the kidney deposits for known contributing proteins was unrevealing. Biochemical analysis of the fibrils identified a new amyloid subunit protein, leukocyte chemotactic factor 2, originally identified as a possible chemotactic and growth factor. A monoclonal antibody to this protein reacted specifically with the amyloid deposits in the glomeruli and interstitium by immunohistochemistry. This study emphasizes the importance of biochemical characterization of amyloid present in renal biopsies.
引用
收藏
页码:218 / 222
页数:5
相关论文
共 18 条
[2]
MAJOR PROTEINS OF HUMAN AND MONKEY AMYLOID SUBSTANCE - COMMON PROPERTIES INCLUDING UNUSUAL N-TERMINAL AMINO ACID SEQUENCES [J].
BENDITT, EP ;
ERIKSEN, N ;
HERMODSON, MA ;
ERICSSON, LH .
FEBS LETTERS, 1971, 19 (02) :169-+
[3]
HEREDITARY RENAL AMYLOIDOSIS ASSOCIATED WITH A MUTANT FIBRINOGEN ALPHA-CHAIN [J].
BENSON, MD ;
LIEPNIEKS, J ;
UEMICHI, T ;
WHEELER, G ;
CORREA, R .
NATURE GENETICS, 1993, 3 (03) :252-255
[4]
A new human hereditary amyloidosis: The result of a stop-codon mutation in the apolipoprotein AII gene [J].
Benson, MD ;
Liepnieks, JJ ;
Yazaki, M ;
Yamashita, T ;
Asl, KH ;
Guenther, B ;
Kluve-Beckerman, B .
GENOMICS, 2001, 72 (03) :272-277
[5]
BENSON MD, 2001, METABOLIC MOL BASES, P5345
[6]
A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II - Purification and amino acid sequence [J].
Hiraki, Y ;
Inoue, H ;
Kondo, J ;
Kamizono, A ;
Yoshitake, Y ;
Shukunami, C ;
Suzuki, F .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (37) :22657-22662
[7]
AMINO-ACID SEQUENCE OF A MAJOR NONIMMUNOGLOBULIN COMPONENT OF SOME AMYLOID FIBRILS [J].
LEVIN, M ;
PRAS, M ;
FRANGIONE, B ;
FRANKLIN, EC .
JOURNAL OF CLINICAL INVESTIGATION, 1972, 51 (10) :2773-+
[8]
Shoulder-pad sign of amyloidosis: Structure of an Ig kappa III protein [J].
Liepnieks, JJ ;
Burt, C ;
Benson, MD .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2001, 54 (04) :404-408
[9]
Systemic expression of a newly recognized protein, LECT2, in the human body [J].
Nagai, H ;
Hamada, T ;
Uchida, T ;
Yamagoe, S ;
Suzuki, K .
PATHOLOGY INTERNATIONAL, 1998, 48 (11) :882-886
[10]
A MUTATION IN APOLIPOPROTEIN-A-I IN THE IOWA TYPE OF FAMILIAL AMYLOIDOTIC POLYNEUROPATHY [J].
NICHOLS, WC ;
GREGG, RE ;
BREWER, HB ;
BENSON, MD .
GENOMICS, 1990, 8 (02) :318-323