The antihypertensive effect of peptides: A novel alternative to drugs?

被引：247

作者：

Fang Hong ^{[1
]}

Luo Ming ^{[1
]}

Sheng Yi ^{[1
]}

Li Zhanxia ^{[1
]}

Wu Yongquan ^{[1
]}

Liu Chi

机构：

[1] Tongji Univ, Tongji Hosp, Dept Cardiol, Shanghai 200065, Peoples R China

来源：

PEPTIDES | 2008年 / 29卷 / 06期

关键词：

hypertension; bioactive peptides; renin-angiotensin system;

D O I：

10.1016/j.peptides.2008.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Many types of bioactive peptides that inhibit angiotensin I, angiotensin I converting enzyme (ACE) and Ang II type 1 receptor (AT1) in the cardiovascular system contribute to the prevention and treatment of hypertension. These inhibitory peptides are derived from many food proteins or artificial synthetic products. Further research examining the bioavailability of ACE inhibitory peptides will lead to the development of more effective ACE inhibitory peptides and foods. Our research also demonstrates that ACE inhibitory peptide LAP may lower blood pressure with no adverse effects. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1062 / 1071

页数：10

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