Beyond hematoxylin and eosin: the importance of immunohistochemical techniques for evaluating surgically resected constipated patients

被引：9

作者：

Bassotti, G. ^{[1
,2
]}

Villanacci, V. ^{[3
]}

Salerni, B. ^{[4
]}

Maurer, C. A. ^{[5
]}

Cathomas, G. ^{[6
]}

机构：

[1] Osped Santa Maria Misericordia, Clin Gastroenterologia Epatol, I-06156 Perugia, Italy

[2] Univ Perugia, Gastroenterol & Hepatol Sect, Dept Clin & Expt Med, I-06100 Perugia, Italy

[3] Univ Brescia, Pathol Sect 2, Dept Lab Diagnost, Brescia, Italy

[4] Univ Brescia, Surg Chair 2, Dept Surg, Spedali Civili, Brescia, Italy

[5] Liestal Hosp, Dept Surg, Liestal, Switzerland

[6] Liestal Hosp, Cantonal Inst Pathol, Liestal, Switzerland

来源：

TECHNIQUES IN COLOPROCTOLOGY | 2011年 / 15卷 / 04期

关键词：

Constipation; Histology; Immunohistochemistry; Surgery; SLOW-TRANSIT CONSTIPATION; ENTERIC NERVOUS-SYSTEM; GLIAL-CELLS; INTERSTITIAL-CELLS; HUMAN COLON; INTESTINAL PSEUDOOBSTRUCTION; INTRACTABLE CONSTIPATION; IDIOPATHIC CONSTIPATION; OBSTRUCTED DEFECATION; NEURONS;

D O I：

10.1007/s10151-011-0721-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Chronic constipation requiring surgical ablation for intractability is often a frustrating condition from the pathologist's point of view. In fact, limiting the histological examination to only hematoxylin-eosin staining usually yields only the information that there are no abnormalities. By employing some simple and widely available immunohistochemical methods, discussed in this review, it is possible to gather data that may help in explaining the pathophysiological basis of constipation in these patients.

引用

页码：371 / 375

页数：5

共 48 条

[1]

Colonic motility studies in severe chronic constipation: An organic approach to a functional problem [J].

Bassotti G. ;

De Roberto G. ;

Sediari L. ;

Morelli A. .

Techniques in Coloproctology, 2004, 8 (3) :147-150

[2]

The role of glial cells and apoptosis of enteric neurones in the neuropathology of intractable slow transit constipation [J].

Bassotti, G ;

Villanacci, V ;

Maurer, CA ;

Fisogni, S ;

Di Fabio, F ;

Cadei, M ;

Morelli, A ;

Panagiotis, T ;

Cathomas, G ;

Salemi, B .

GUT, 2006, 55 (01) :41-46

[3]

Endoluminal instillation of bisacodyl in patients with severe (slow transit type) constipation is useful to test residual colonic propulsive activity [J].

Bassotti, G ;

Chiarioni, G ;

Germani, U ;

Battaglia, E ;

Vantini, I ;

Morelli, A .

DIGESTION, 1999, 60 (01) :69-73

[4]

Enteric glial cells: new players in gastrointestinal motility? [J].

Bassotti, Gabrio ;

Villanacci, Vincenzo ;

Antonelli, Elisabetta ;

Morelli, Antonio ;

Salerni, Bruno .

LABORATORY INVESTIGATION, 2007, 87 (07) :628-632

[5]

Colonic neuropathological aspects in patients with intractable constipation due to obstructed defecation [J].

Bassotti, Gabrio ;

Villanacci, Vincenzo ;

Nascimbeni, Riccardo ;

Asteria, Corrado R. ;

Fisogni, Simona ;

Nesi, Gabriella ;

Legrenzi, Laura ;

Mariano, Marina ;

Tonelli, Francesco ;

Morelli, Antonio ;

Salerni, Bruno .

MODERN PATHOLOGY, 2007, 20 (03) :367-374

[6]

Apoptotic phenomena are not a major cause of enteric neuronal loss in constipated patients with dementia [J].

Bassotti, Gabrio ;

Villanacci, Vincenzo ;

Fisogni, Simona ;

Cadei, Morris ;

Di Fabio, Francesco ;

Salerni, Bruno .

NEUROPATHOLOGY, 2007, 27 (01) :67-72

[7]

Comparison of three methods to assess enteric neuronal apoptosis in patients with slow transit constipation [J].

Bassotti, Gabrio ;

Villanacci, Vincenzo ;

Fisogni, Simona ;

Cadei, Moris ;

Galletti, Anna ;

Morelli, Antonio ;

Salerni, Bruno .

APOPTOSIS, 2007, 12 (02) :329-332

[8]

Slow transit constipation: A functional disorder becomes an enteric neuropathy [J].

Bassotti, Gabrio ;

Villanacci, Vincenzo .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (29) :4609-4613

[9]

Toward a definition of colonic inertia [J].

Bassotti, Gabrio ;

de Roberto, Giuseppe ;

Sediari, Luca ;

Morelli, Antonio .

WORLD JOURNAL OF GASTROENTEROLOGY, 2004, 10 (17) :2465-2467

[10]

Can "Functional" Constipation Be Considered as a Form of Enteric Neuro-Gliopathy? [J].

Bassotti, Gabrio ;

Villanacci, Vincenzo .

GLIA, 2011, 59 (03) :345-350

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