Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior

被引:69
作者
Nakamura, Keiko [1 ,2 ]
Itoh, Kyoko [1 ]
Dai, Hongmei [1 ]
Han, Longzhe [1 ]
Wang, Xiaohang [1 ]
Kato, Shingo [1 ]
Sugimoto, Tohru [2 ]
Fushiki, Shinji [1 ]
机构
[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pathol & Appl Neurobiol, Kyoto 602, Japan
[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto 602, Japan
关键词
Bisphenol A; Endocrine-disrupting chemicals; Development; Behavior; PERFORMANCE LIQUID-CHROMATOGRAPHY; SEX-DIFFERENCES; NEONATAL EXPOSURE; DEVELOPMENTAL EXPOSURE; PERINATAL EXPOSURE; FEMALE RATS; WATER-MAZE; OPEN-FIELD; IN-VITRO; BRAIN;
D O I
10.1016/j.braindev.2010.12.011
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Bisphenol A (BPA) is an endocrine-disrupting chemical, widely used in dentistry and various industries. We previously reported that BPA affected murine neocortical development by accelerating neuronal differentiation/migration, resulting in abnormal neocortical architecture as well as aberrant thalamocortical connections in the brains of adult mice. The aim of this study was to investigate whether prenatal and lactational BPA exposure affected behavior in adult mice. Pregnant mice were injected subcutaneously with 20 mu g/kg of BPA daily from embryonic day 0 (E0) until postnatal day 21 (P21). Control animals received a vehicle alone. Behavioral tests (n = 15-20) were conducted at postnatal 3 weeks (P3W) and P10-15W. After an open-field test, an elevated plus maze and Morris water maze tests were performed. The total distance in the elevated plus maze test at P3W and in the open-field test at P10W was significantly decreased in the BPA-exposed group, compared with the control group. Significant sex differences were observed in the time spent in the central area in the open-field test at P3W and in the total distance in the elevated plus maze test at P11W. These results indicated that prenatal and lactational BPA exposure disturbed the murine behavior in the postnatal development period and the adult mice. (C) 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:57 / 63
页数:7
相关论文
共 39 条
[1]
RODENT SEX-DIFFERENCES IN EMOTIONAL AND RELATED BEHAVIOR [J].
ARCHER, J .
BEHAVIORAL BIOLOGY, 1975, 14 (04) :451-479
[2]
SEX-DIFFERENCES IN OPEN-FIELD BEHAVIOR IN RAT - INDUCTIVE AND ACTIVATIONAL ROLE OF GONADAL HORMONES [J].
BLIZARD, DA ;
LIPPMAN, HR ;
CHEN, JJ .
PHYSIOLOGY & BEHAVIOR, 1975, 14 (05) :601-608
[3]
Effect of neonatal rat bisphenol A exposure on performance in the Morris water maze [J].
Carr, RL ;
Bertasi, FR ;
Betancourt, AM ;
Bowers, SD ;
Gandy, BS ;
Ryan, PL ;
Willard, ST .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2003, 66 (21) :2077-2088
[4]
Rat two-generation reproductive toxicity study of bisphenol A [J].
Ema, M ;
Fujii, S ;
Furukawa, M ;
Kiguchi, M ;
Ikka, T ;
Harazono, A .
REPRODUCTIVE TOXICOLOGY, 2001, 15 (05) :505-523
[5]
Perinatal exposure to the estrogenic pollutant Bisphenol A affects behavior in male and female rats [J].
Farabollini, F ;
Porrini, S ;
Dessì-Fulgheri, F .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1999, 64 (04) :687-694
[6]
Prenatal exposure to bisphenol A impairs sexual differentiation of exploratory behavior and increases depression-like behavior in rats [J].
Fujimoto, T ;
Kubo, K ;
Aou, S .
BRAIN RESEARCH, 2006, 1068 (01) :49-55
[7]
Short- and long-term effects of low-dose prenatal X-irradiation in mouse cerebral cortex, with special reference to neuronal migration [J].
Fushiki, S ;
HyodoTaguchi, Y ;
Kinoshita, C ;
Ishikawa, Y ;
Hirobe, T .
ACTA NEUROPATHOLOGICA, 1997, 93 (05) :443-449
[8]
Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in mice [J].
Gioiosa, Laura ;
Fissore, Elena ;
Ghirardelli, Giorgia ;
Parmigiani, Stefano ;
Palanza, Paola .
HORMONES AND BEHAVIOR, 2007, 52 (03) :307-316
[9]
Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction [J].
Honma, S ;
Suzuki, A ;
Buchanan, DL ;
Katsu, Y ;
Watanabe, H ;
Iguchi, T .
REPRODUCTIVE TOXICOLOGY, 2002, 16 (02) :117-122
[10]
Environmental toxins - Exposure to bisphenol A advances puberty [J].
Howdeshell, KL ;
Hotchkiss, AK ;
Thayer, KA ;
Vandenbergh, JG ;
vom Saal, FS .
NATURE, 1999, 401 (6755) :763-764