Ryanodine Receptor S2808 Phosphorylation in Heart Failure Smoking Gun or Red Herring

被引:82
作者
Bers, Donald M. [1 ]
机构
[1] Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USA
关键词
Ca2+; regulation; cardiac failure; protein kinase A phosphorylation; ryanodine receptor; sarcoplasmic reticulum; KINASE-A PHOSPHORYLATION; RETICULUM CA2+ LEAK; FK506-BINDING PROTEIN FKBP12.6; MOUSE VENTRICULAR MYOCYTES; AFFECT CALCIUM SPARKS; SUDDEN CARDIAC DEATH; PKA PHOSPHORYLATION; FLIGHT RESPONSE; RELEASE; MICE;
D O I
10.1161/CIRCRESAHA.112.265579
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
[No abstract available]
引用
收藏
页码:796 / 799
页数:4
相关论文
共 34 条
[1]
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure [J].
Ai, X ;
Curran, JW ;
Shannon, TR ;
Bers, DM ;
Pogwizd, SM .
CIRCULATION RESEARCH, 2005, 97 (12) :1314-1322
[2]
Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity [J].
Bellinger, Andrew M. ;
Reiken, Steven ;
Dura, Miroslav ;
Murphy, Peter W. ;
Deng, Shi-Xian ;
Landry, Donald W. ;
Nieman, David ;
Lehnart, Stephan E. ;
Samaru, Mahendranauth ;
LaCampagne, Alain ;
Marks, Andrew R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (06) :2198-2202
[3]
Intact β-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase a phosphorylation site in the cardiac ryanodine receptor [J].
Benkusky, Nancy A. ;
Weber, Craig S. ;
Scherman, Joseph A. ;
Farrell, Emily F. ;
Hacker, Timothy A. ;
John, Manorama C. ;
Powers, Patricia A. ;
Valdivia, Hector H. .
CIRCULATION RESEARCH, 2007, 101 (08) :819-829
[4]
Calcium cycling and signaling in cardiac myocytes [J].
Bers, Donald M. .
ANNUAL REVIEW OF PHYSIOLOGY, 2008, 70 :23-49
[5]
β-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase [J].
Curran, Jerald ;
Hinton, Mark J. ;
Rios, Eduardo ;
Bers, Donald M. ;
Shannon, Thomas R. .
CIRCULATION RESEARCH, 2007, 100 (03) :391-398
[6]
What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? [J].
Eisner, D. A. ;
Kashimura, T. ;
O'Neill, S. C. ;
Venetucci, L. A. ;
Trafford, A. W. .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2009, 46 (04) :474-481
[7]
CaMKII IN THE CARDIOVASCULAR SYSTEM: SENSING REDOX STATES [J].
Erickson, Jeffrey R. ;
He, B. Julie ;
Grumbach, Isabella M. ;
Anderson, Mark E. .
PHYSIOLOGICAL REVIEWS, 2011, 91 (03) :889-915
[8]
Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure? [J].
Eschenhagen, Thomas .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (12) :4197-4203
[9]
Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling [J].
Gellen, Barnabas ;
Fernandez-Velasco, Maria ;
Briec, Francois ;
Vinet, Laurent ;
LeQuang, Khai ;
Rouet-Benzineb, Patricia ;
Benitah, Jean-Pierre ;
Pezet, Mylene ;
Palais, Gael ;
Pellegrin, Noemie ;
Zhang, Andy ;
Perrier, Romain ;
Escoubet, Brigitte ;
Marniquet, Xavier ;
Richard, Sylvain ;
Jaisser, Frederic ;
Gomez, Ana Maria ;
Charpentier, Flavien ;
Mercadier, Jean-Jacques .
CIRCULATION, 2008, 117 (14) :1778-1786
[10]
Sarcoplasmic reticulum Ca2+ leak in heart failure:: mere observation or functional relevance? [J].
George, Christopher H. .
CARDIOVASCULAR RESEARCH, 2008, 77 (02) :302-314