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Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery

被引：72
作者：
Abbas, Aiman O. [1 ]
Donovan, Maureen D. [1 ]
Salem, Aliasger K. [1 ]
机构：
[1] Univ Iowa, Coll Pharm, Div Pharmaceut, Iowa City, IA 52242 USA
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 97卷 / 07期
关键词：
DNA delivery; formulation; gene delivery; microparticles; plasmid DNA; poly(lactide-co-glycolide) (PLGA); polymeric drug delivery systems;
D O I：
10.1002/jps.21215
中图分类号：
R914 [药物化学];
学科分类号：
100701 [药物化学];
摘要：
Biodegradable poly(lactide-co-glycolide) (PLGA) particles have shown significant potential for sustained and targeted delivery of several pharmaceutical agents, including plasmid DNA (pDNA). Here, we survey current approaches to PLGA particle preparation for pDNA delivery and discuss recent progress on optimizing formulation development. (C) 2007 Wiley-Liss, Inc.
引用
收藏
页码：2448 / 2461
页数：14
相关论文
共 99 条
[1]
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis [J].
Akinc, A ;
Thomas, M ;
Klibanov, AM ;
Langer, R .
JOURNAL OF GENE MEDICINE, 2005, 7 (05) :657-663
[2]
Biodegradation and biocompatibility of PLA and PLGA microspheres [J].
Anderson, JM ;
Shive, MS .
ADVANCED DRUG DELIVERY REVIEWS, 1997, 28 (01) :5-24
[3]
PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization [J].
Ando, S ;
Putnam, D ;
Pack, DW ;
Langer, R .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 88 (01) :126-130
[4]
PLGA nanoparticles in drug delivery: The state of the art [J].
Bala, I ;
Hariharan, S ;
Kumar, MNVR .
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2004, 21 (05) :387-422
[5]
Dendritic cells and the control of immunity [J].
Banchereau, J ;
Steinman, RM .
NATURE, 1998, 392 (6673) :245-252
[6]
Bergstrom DE, 1998, BIOTECHNIQUES, V24, P992
[7]
PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium [J].
Bivas-Benita, M ;
Romeijn, S ;
Junginger, HE ;
Borchard, G .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 58 (01) :1-6
[8]
Bowman K, 2004, MOL THER, V9, pS314
[9]
Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres containing poly(L-lysine) complexed plasmid DNA [J].
Capan, Y ;
Woo, BH ;
Gebrekidan, S ;
Ahmed, S ;
DeLuca, PP .
JOURNAL OF CONTROLLED RELEASE, 1999, 60 (2-3) :279-286
[10]
Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA [J].
Capan, Y ;
Woo, BH ;
Gebrekidan, S ;
Ahmed, S ;
DeLuca, PP .
PHARMACEUTICAL RESEARCH, 1999, 16 (04) :509-513
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