Effect of electroconvulsive therapy in repetitive transcranial magnetic stimulation non-responder MDD patients: a preliminary study

被引:21
作者
Dannon, PN [1 ]
Grunhaus, L [1 ]
机构
[1] Chaim Sheba Med Ctr, ECT TMS Unit, IL-52621 Tel Hashomer, Israel
关键词
electroconvulsive therapy; major depressive disorder; psychotic depression; repetitive transcranial magnetic stimulation;
D O I
10.1017/S1461145701002498
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of this study was to measure the effectiveness of ECT in-patients who had failed to respond to a course of repetitive transcranial magnetic stimulation (rTMS) treatment. Seventeen patients with severe MDD who had not responded to a course of rTMS were switched to receive ECT treatments. All the patients were assessed with the Hamilton Rating Scale for Depression, the Global Assessment Functioning Scale, the Global Depression Scale, and the Pittsburgh Sleep Quality Index. Response to the treatment was defined as a 50% decrease in HDRS final score and a final GAS higher than 60. Seven out of 17 patients responded to ECT. Three out of 5 non-psychotics and 4 out of 12 psychotic patients responded. ECT seems to be an effective treatment for 40% of patients who failed to respond to rTMS treatment. Whether this is a result of reduced responsiveness to ECT in rTMS-resistant patients or a consequence of small sample size requires further study.
引用
收藏
页码:265 / 268
页数:4
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