A Taenia solium oncosphere protein homologous to host-protective Taenia ovis and Taenia saginata 18 kDa antigens

被引：54

作者：

Gauci, CGP

Flisser, A

Lightowlers, MW

机构：

[1] Univ Melbourne, Mol Parasitol Lab, Werribee, Vic 3030, Australia

[2] Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Mexico City 04510, DF, Mexico

[3] Inst Nacl Diagnost & Referencia Epidemiol, SSa, Mexico City 11340, DF, Mexico

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1998年 / 28卷 / 05期

基金：

英国医学研究理事会;

关键词：

Taenia solium; oncosphere; host protection;

D O I：

10.1016/S0020-7519(98)00034-4

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

A Taenia solium cDNA (TSOL-18) encoding a protein with close homology to host protective oncosphere antigens from Taenia ovis (To18) and Taenia saginata (TSA-18) is described here. TSOL-18 was cloned from mRNA obtained from hatched and activated oncospheres of T. solium. The high level of predicted amino acid sequence homology among TSOL-18 and other host protective taeniid antigens suggests that the protein expressed by TSOL-18 may be capable of being used as a vaccine against T. solium infection in the parasite's intermediate hosts. (C) 1998 Australian Society for Parasitology. Published by Elsevier Science Ltd.

引用

页码：757 / 760

页数：4

共 13 条

[1] Cloning and sequencing of the gene encoding the principal 18-kDa secreted antigen of activated oncospheres of Taenia saginata [J].