FYVE fingers bind Ptdins(3)P

被引：476

作者：

Gaullier, JM ^{[1
]}

Simonsen, A

D'Arrigo, A

Bremnes, B

Stenmark, H

Aasland, R

机构：

[1] Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway

[2] Univ Bergen, Dept Biol Mol, N-5020 Bergen, Norway

来源：

NATURE | 1998年 / 394卷 / 6692期

关键词：

D O I：

10.1038/28767

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) is constitutively produced by yeast and higher eukaryotes through the phosphorylation of phosphatidylinositol by phosphatidylinositol-3-OH kinase1 (PI(3)K). PtdIns(3)P is important for vesicular transport1, but little is known about how it acts, and proteins that specifically recognize it have not yet been identified. Here we identify the FYVE finger2, an evolutionarily conserved double-zinc-binding domain (see Supplementary information), as a protein structure that binds to PtdIns(3)P with high specificity.

引用

页码：432 / 433

页数：2

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