Analytical methods for the quantitative determination of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in biological samples

被引：72

作者：

Ertürk, S ^{[1
]}

Önal, A ^{[1
]}

Çetin, SM ^{[1
]}

机构：

[1] Istanbul Univ, Fac Pharm, Dept Analyt Chem, TR-34116 Istanbul, Turkey

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2003年 / 793卷 / 02期

关键词：

reviews; 3-hydroxy-3-methylglutaryl;

D O I：

10.1016/S1570-0232(03)00314-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Published analytical methods for the quantitative determinations of presently available five 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ("statins"), lovastatin, simvastatin, pravastatin, fluvastatin and atorvastatin, are reviewed for therapeutic drug monitoring purpose in patients. Almost all assay reviewed are based on hi h-performance liquid chromatography or gas chromatography. Some purification steps (liquid-liquid extraction, solid-phase extraction, etc.) have been used before they are submitted to separation by chromatographic procedures and they are detected by various detection methods like UV. fluorescence and mass spectrometry. This review shows that most method may be used quantitative determination of statins in plasma and they are suitable for therapeutic drug monitoring purpose of these drugs. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：193 / 205

页数：13

共 91 条

[1]

MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].

ALBERTS, AW ;

CHEN, J ;

KURON, G ;

HUNT, V ;

HUFF, J ;

HOFFMAN, C ;

ROTHROCK, J ;

LOPEZ, M ;

JOSHUA, H ;

HARRIS, E ;

PATCHETT, A ;

MONAGHAN, R ;

CURRIE, S ;

STAPLEY, E ;

ALBERSSCHONBERG, G ;

HENSENS, O ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

LIESCH, J ;

SPRINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961

[2]

CHOLESTEROL AND MORTALITY - 30 YEARS OF FOLLOW-UP FROM THE FRAMINGHAM-STUDY [J].

ANDERSON, KM ;

CASTELLI, WP ;

LEVY, D .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 257 (16) :2176-2180

[3]

[Anonymous], 1993, Am J Cardiol, V72, P1031

[4]

EFFECTS OF LOVASTATIN THERAPY ON VERY-LOW-DENSITY LIPOPROTEIN TRIGLYCERIDE-METABOLISM IN SUBJECTS WITH COMBINED HYPERLIPIDEMIA - EVIDENCE FOR REDUCED ASSEMBLY AND SECRETION OF TRIGLYCERIDE-RICH LIPOPROTEINS [J].

ARAD, Y ;

RAMAKRISHNAN, R ;

GINSBERG, HN .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1992, 41 (05) :487-493

[5]

MANAGEMENT OF HYPERLIPEMIA - GUIDELINES OF THE BRITISH-HYPERLIPEMIA-ASSOCIATION [J].

BETTERIDGE, DJ ;

DODSON, PM ;

DURRINGTON, PN ;

HUGHES, EA ;

LAKER, MF ;

NICHOLLS, DP ;

REES, JAE ;

SEYMOUR, CA ;

THOMPSON, GR ;

WINDER, AF ;

WINOCOUR, PH ;

WRAY, R .

POSTGRADUATE MEDICAL JOURNAL, 1993, 69 (811) :359-369

[6]

MEVINOLIN AND COLESTIPOL STIMULATE RECEPTOR-MEDIATED CLEARANCE OF LOW-DENSITY LIPOPROTEIN FROM PLASMA IN FAMILIAL HYPERCHOLESTEROLEMIA HETEROZYGOTES [J].

BILHEIMER, DW ;

GRUNDY, SM ;

BROWN, MS ;

GOLDSTEIN, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13) :4124-4128

[7]

COMPARISON OF PROPERTIES OF 4 INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE [J].

BLUM, CB .

AMERICAN JOURNAL OF CARDIOLOGY, 1994, 73 (14) :D3-D11

[8]

Development and validation of a high-performance liquid chromatography tandem mass spectrometry assay for atorvastatin, ortho-hydroxy atorvastatin, and para-hydroxy atorvastatin in human, dog, and rat plasma [J].

Bullen, WW ;

Miller, RA ;

Hayes, RN .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1999, 10 (01) :55-66

[9]

REDUCTION IN CARDIOVASCULAR EVENTS DURING PRAVASTATIN THERAPY - POOLED ANALYSIS OF CLINICAL EVENTS OF THE PRAVASTATIN ATHEROSCLEROSIS INTERVENTION PROGRAM [J].

BYINGTON, RP ;

JUKEMA, JW ;

SALONEN, JT ;

PITT, B ;

BRUSCHKE, AV ;

HOEN, H ;

FURBERG, CD ;

MANCINI, J .

CIRCULATION, 1995, 92 (09) :2419-2425

[10]

CAI K, 1996, SEPU, V14, P121

← 1 2 3 4 5 6 7 8 9 10 →