A facile and new approach to synthesize 2-amino-4-(4-amoinophenyl)-1H-1,3-diazol-1-yl-alkylaminomethanethiones

被引：2

作者：

Verma, Raman K. ^{[1
]}

Aggarwal, Monika ^{[1
]}

Bansal, Manisha ^{[1
]}

Kaur, Inder Preet ^{[1
]}

机构：

[1] Punjabi Univ, Dept Chem, Synth Organ & Med Chem Lab, Patiala 147002, Punjab, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2007年 / 15卷 / 09期

关键词：

airway hyperresponsiveness; alkyl-isothiocyanates; 2-aminoimidazole; Antiasthmatic agents; benzidine; eosinophils; interleukin-5;

D O I：

10.1007/s00044-007-9003-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An "intellectual connection" approach to design a facile and new synthesis of suitably substituted 2-aminoimidazole-based precursors of expected antiasthmatic agents through a benzidine type of rearrangement of 2-phenylazoimidazole and subsequent coupling of the product thus obtained with alkylisothiocyanates involving a degenerative operation, thereby improving the time frame of the overall synthetic sequence, is reported. The alkylisothiocyanates required in this synthetic sequence are prepared using a best combination of reported methods. The compounds reported here can be used to produce derivatives of other biological agents.

引用

页码：483 / 491

页数：9

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