Autoimmune aspects of cytokine and anticytokine therapies

被引：67

作者：

Krause, I

Valesini, G

Scrivo, R

Shoenfeld, Y ^{[1
]}

机构：

[1] Chaim Sheba Med Ctr, Ctr Autoimmune Dis, Dept Med B, IL-52621 Tel Hashomer, Israel

[2] Schneider Childrens Med Ctr Israel, Nephrol & Dialysis Unit, Petah Tiqwa, Israel

[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[4] Tel Aviv Univ, Schwartz Kip Chair Res Autoimmun, Incumbent Laura, IL-69978 Tel Aviv, Israel

[5] Univ Roma La Sapienza, Cattedra Reumatol, Rome, Italy

来源：

AMERICAN JOURNAL OF MEDICINE | 2003年 / 115卷 / 05期

关键词：

D O I：

10.1016/S0002-9343(03)00390-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cytokines and anticytokines are used increasingly in the treatment of immune, autoimmune, inflammatory, infectious, and malignant disorders. Commonly used treatments include the anti-tumor necrosis factor agents interferon alpha, interferon beta, interferon gamma, and interleukin 2. Several autoimmune phenomena have been reported in patients treated with these substances. This review summarizes the published data on the autoimmune, manifestations associated with cytokine and anticytokine therapies, as well as describes possible mechanisms of these phenomena. (C) 2003 by Excerpta Medica Inc.

引用

页码：390 / 397

页数：8

共 103 条

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