Effects of hormone replacement therapy on QT interval

被引：62

作者：

Larsen, JA ^{[1
]}

Tung, RH ^{[1
]}

Sadananda, R ^{[1
]}

Goldberger, JJ ^{[1
]}

Horvath, G ^{[1
]}

Parker, MA ^{[1
]}

Kadish, AH ^{[1
]}

机构：

[1] Northwestern Univ, Sch Med, Dept Internal Med, Div Cardiol, Chicago, IL USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1998年 / 82卷 / 08期

关键词：

D O I：

10.1016/S0002-9149(98)00523-2

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We evaluated the electrocardiograms of 208 postmenopausal women (ages 40 to greater than or equal to 70 years) without heart disease, medications that could alter the QT interval, use of vaginal estrogens, unknown hormone replacement therapy, or electrocardiographic abnormalities both with (n = 76) and without (n = 132) hormone replacement therapy, and found no significant effects of hormone replacement therapy status on heart rate, QT interval, or the corrected QT interval. Thus, estrogen and/or progesterone effect does not explain the gender differences in myocardial repolarization.

引用

页码：993 / +

页数：4

共 19 条

[1]

QTC PROLONGATION MEASURED BY STANDARD 12-LEAD ELECTROCARDIOGRAPHY IS AN INDEPENDENT RISK FACTOR FOR SUDDEN-DEATH DUE TO CARDIAC-ARREST [J].

ALGRA, A ;

TIJSSEN, JGP ;

ROELANDT, JRTC ;

POOL, J ;

LUBSEN, J .

CIRCULATION, 1991, 83 (06) :1888-1894

[2]

Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart [J].

Drici, MD ;

Burklow, TR ;

Haridasse, V ;

Glazer, RI ;

Woosley, RL .

CIRCULATION, 1996, 94 (06) :1471-1474

[3]

ACTION OF SEX STEROIDS ON ELECTRICAL AND MECHANICAL PROPERTIES OF RAT ATRIUM [J].

GIMENO, AL ;

WEBB, JL ;

GIMENO, MF .

AMERICAN JOURNAL OF PHYSIOLOGY, 1963, 205 (01) :198-+

[4]

INCREASED PROPENSITY OF WOMEN TO DEVELOP TORSADES-DE-POINTES DURING COMPLETE HEART-BLOCK [J].

KAWASAKI, R ;

MACHADO, C ;

REINOEHL, J ;

FROMM, B ;

BAGA, JJ ;

STEINMAN, RT ;

LEHMANN, MH .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 1995, 6 (11) :1032-1038

[5]

KLAPHOLZ M, 1993, CARDIOVASCULAR HLTH, P107

[6]

Lehmann Michael H., 1996, Circulation, V94, P2534

[7]

FEMALE GENDER AS A RISK FACTOR FOR TORSADES-DE-POINTES ASSOCIATED WITH CARDIOVASCULAR DRUGS [J].

MAKKAR, RR ;

FROMM, BS ;

STEINMAN, RT ;

MEISSNER, MD ;

LEHMANN, MH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (21) :2590-2597

[8]

ELECTROCARDIOGRAPHIC QUANTITATION OF VENTRICULAR REPOLARIZATION [J].

MERRI, M ;

BENHORIN, J ;

ALBERTI, M ;

LOCATI, E ;

MOSS, AJ .

CIRCULATION, 1989, 80 (05) :1301-1308

[9]

THE LONG QT SYNDROME - PROSPECTIVE LONGITUDINAL-STUDY OF 328 FAMILIES [J].

MOSS, AJ ;

SCHWARTZ, PJ ;

CRAMPTON, RS ;

TZIVONI, D ;

LOCATI, EH ;

MACCLUER, J ;

HALL, WJ ;

WEITKAMP, L ;

VINCENT, GM ;

GARSON, A ;

ROBINSON, JL ;

BENHORIN, J ;

CHOI, SS .

CIRCULATION, 1991, 84 (03) :1136-1144

[10]

MOSS AJ, 1982, MOD CONC CARDIOV DIS, V51, P85

← 1 2 →