Neuroprotective effects of diallyl trisulfide in SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis

被引：29

作者：

Guo, Yansu ^{[1
,2
,3
]}

Zhang, Kunxi ^{[1
]}

Wang, Qian ^{[1
]}

Li, Zhongyao ^{[1
,2
,3
]}

Yin, Yunxia ^{[1
]}

Xu, Qingmei ^{[1
]}

Duan, Weisong ^{[1
,2
,3
]}

Li, Chunyan ^{[1
,2
,3
]}

机构：

[1] Hebei Med Univ, Dept Neurol, Hosp 2, Shijiazhuang 050000, Hebei Province, Peoples R China

[2] Inst Cardiocerebrovasc Dis, Shijiazhuang 050000, Hebei, Peoples R China

[3] Neurol Lab Hebei Prov, Shijiazhuang 050000, Hebei, Peoples R China

来源：

BRAIN RESEARCH | 2011年 / 1374卷

基金：

中国国家自然科学基金;

关键词：

Amyotrophic lateral sclerosis; Cu/Zn superoxide dismutase; Transgenic mouse; Diallyl trisulfide; Neuroprotection; MOTOR-NEURON DEGENERATION; OXIDATIVE STRESS; HEME OXYGENASE-1; THERAPEUTIC TARGET; MICE; ALS; PATHOGENESIS; INDUCTION; DISEASE; ENZYMES;

D O I：

10.1016/j.brainres.2010.12.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Diallyl trisulfide (DAIS) is one of the major constituents in garlic oil and has been documented to transcriptionally activate phase II enzymes. The purpose of this study is to evaluate the effects of DAIS in prolonging disease duration and survival in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). SOD1-G93A transgenic mice were randomly divided into DATS-treated group (80 mg/kg/d, p.o.) and vehicle-treated group at disease onset stage. Oral administration of DATS beginning at clinical onset stage significantly prolonged disease duration and extended life span for about one week. DATS treatment induced HO-1 and reduced GFAP expression in the lumbar spinal cord of SOD1-G93A transgenic mice. This study indicates that DATS has multifunctional neuroprotective effects in SOD1-G93A transgenic mice. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：110 / 115

页数：6

共 26 条

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Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target [J].