A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion

被引：655

作者：

Overholtzer, Michael ^{[1
]}

Mailleux, Arnaud A. ^{[1
]}

Mouneimne, Ghassan ^{[1
]}

Normand, Guillaume ^{[1
]}

Schnitt, Stuart J. ^{[3
]}

King, Randall W. ^{[1
]}

Cibas, Edmund S. ^{[2
]}

Brugge, Joan S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Cambridge, MA 02138 USA

[2] Brigham & Womens Hosp, Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA

[3] Beth Israel Deaconess Med Ctr, Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA

来源：

CELL | 2007年 / 131卷 / 05期

关键词：

D O I：

10.1016/j.cell.2007.10.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Epithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic cell death program termed anoikis. Here we describe a nonapoptotic cell death program in matrix-detached cells that is initiated by a previously unrecognized and unusual process involving the invasion of one cell into another, leading to a transient state in which a live cell is contained within a neighboring host cell. Live internalized cells are either degraded by lysosomal enzymes or released. We term this cell internalization process entosis and present evidence for entosis as a mechanism underlying the commonly observed "cell-in-cell'' cytological feature in human cancers. Further we propose that entosis is driven by compaction force associated with adherens junction formation in the absence of integrin engagement and may represent an intrinsic tumor suppression mechanism for cells that are detached from ECM.

引用

页码：966 / 979

页数：14

共 36 条

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