Comparative induction of long-term depression between dorsal and ventral hippocampal CA1 in the anesthetized rat

被引：17

作者：

Izaki, Y ^{[1
]}

Takita, M

Nomura, M

机构：

[1] Saitama Med Sch, Dept Physiol, Moroyama, Saitama 3500495, Japan

[2] Natl Inst Biosci & Human Technol, Neuroinformat Lab, Tsukuba, Ibaraki, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 294卷 / 03期

关键词：

ventral hippocampus; dorsal hippocampus; long-term depression; in vivo; rats;

D O I：

10.1016/S0304-3940(00)01570-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied whether a protocol reported as in vivo prefrontal long-term depression (LTD) induction protocol, also induced LTD in the anesthetized rat hippocampal CA1,and whether differences in LTD induction existed between dorsal and ventral CA1, by low-frequency stimulation (LFS) ( 1 Hz, 900) or low-frequency bu rst stimulation (LFBS) (5-pulse burst at 4 ms interpulse intervals at 1 Hz, 900), hippocampo-prefrontal LTD induction protocol. Though LFS failed to induce stable LTD in dorsal or ventral CA1, LFBS reliably induced LTD in the ventral not dorsal CA1. This similarity between ventral hippocampal and hippocampo-prefrontal LTD induction thus implies their serial integration process, ventral CA3-CA1-prefrontal cortex pathway and observed dorsal and ventral differences involved in behavioral functions such as learning. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：171 / 174

页数：4

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