Analgesic activity of the lignans from Lychnophora ericoides

被引：82

作者：

Borsato, MLC ^{[1
]}

Grael, CFF ^{[1
]}

Souza, GEP ^{[1
]}

Lopes, NP ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

PHYTOCHEMISTRY | 2000年 / 55卷 / 07期

基金：

巴西圣保罗研究基金会;

关键词：

Lychnophora ericoides; Asteraceae; lignans; analgesic activity; methylclusin; cubebin;

D O I：

10.1016/S0031-9422(00)00388-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lychnophora ericoides is a Brazilian medicinal plant that is commercially available as an analgesic and anti-inflammatory agent. The extract from roots, which yielded 10 lignans, showed analgesic activity in the mouse writhing test and the lignan, cubebin, was one of the most active. Anti-inflammatory and anti-pyretic activities from cubebin (10 mg/kg) revealed no significant effects. In addition two previously unknown methyl clusin derivatives are reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：809 / 813

页数：5

共 31 条

[1] LIGNANS FROM PIPER-CUBEBA .3. LIGNANS OF PIPER-CUBEBA [J].

BADHEKA, LP ;

PRABHU, BR ;

MULCHANDANI, NB .

PHYTOCHEMISTRY, 1987, 26 (07) :2033-2036

[2] CHEMISTRY AND SYNTHESIS OF LIGNAN(-)-CUBEBIN [J].

BATTERBEE, JE ;

BURDEN, RS ;

CROMBIE, L ;

WHITING, DA .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1969, (18) :2470-+

[3]

Bazon J. N., 1997, Fitoterapia, V68, P92

[4]

Blumenthal EEDA, 1997, PHYTOCHEMISTRY, V46, P745

[5]

BOHLMANN F, 1990, PLANT SYSTEMATICS AND EVOLUTION, SUPPL 4, P3

[6] Sesquiterpene lactones, triterpenes and flavones from Lychnophora ericoides and Lychnophora pseudovillosissima [J].

Borella, JC ;

Lopes, JLC ;

Vichnewski, W ;

Cunha, WR ;

Herz, W .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 1998, 26 (06) :671-676

[7] SCREENING INVITRO OF NATURAL-PRODUCTS AGAINST BLOOD FORMS OF TRYPANOSOMA-CRUZI [J].

CHIARI, E ;

DEOLIVEIRA, AB ;

RASLAN, DS ;

MESQUITA, AAL ;

TAVARES, KG .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (03) :372-374

[8]

Chiari E, 1996, PHYTOTHER RES, V10, P636, DOI 10.1002/(SICI)1099-1573(199611)10:7&lt

[9]

636::AID-PTR921&gt

[10]

3.0.CO

← 1 2 3 4 →