共 21 条
Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses
被引:74
作者:

Uhlig, HH
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

Powrie, F
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
机构:
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
关键词:
D O I:
10.1172/JC1200319545
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Mammals coexist in an overall symbiotic relationship with a complex array of commensal bacterial flora that colonizes the gastrointestinal tract. These intestinal bacteria interface with cells of the mucosal immune system, including DCs (see the related article beginning on page 693). Here we discuss mechanisms of interaction between intestinal bacteria and DCs and the role of localized gastrointestinal immune responses.
引用
收藏
页码:648 / 651
页数:4
相关论文
共 21 条
[1]
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
[J].
Becker, C
;
Wirtz, S
;
Blessing, M
;
Pirhonen, J
;
Strand, D
;
Bechthold, O
;
Frick, J
;
Galle, PR
;
Autenrieth, I
;
Neurath, MF
.
JOURNAL OF CLINICAL INVESTIGATION,
2003, 112 (05)
:693-706

论文数: 引用数:
h-index:
机构:

Wirtz, S
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin, Lab Immunol 1, D-55101 Mainz, Germany

Blessing, M
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin, Lab Immunol 1, D-55101 Mainz, Germany

Pirhonen, J
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin, Lab Immunol 1, D-55101 Mainz, Germany

Strand, D
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin, Lab Immunol 1, D-55101 Mainz, Germany

Bechthold, O
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin, Lab Immunol 1, D-55101 Mainz, Germany

Frick, J
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin, Lab Immunol 1, D-55101 Mainz, Germany

论文数: 引用数:
h-index:
机构:

Autenrieth, I
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin, Lab Immunol 1, D-55101 Mainz, Germany

Neurath, MF
论文数: 0 引用数: 0
h-index: 0
机构: Johannes Gutenberg Univ Mainz, Med Clin, Lab Immunol 1, D-55101 Mainz, Germany
[2]
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
[J].
Cua, DJ
;
Sherlock, J
;
Chen, Y
;
Murphy, CA
;
Joyce, B
;
Seymour, B
;
Lucian, L
;
To, W
;
Kwan, S
;
Churakova, T
;
Zurawski, S
;
Wiekowski, M
;
Lira, SA
;
Gorman, D
;
Kastelein, RA
;
Sedgwick, JD
.
NATURE,
2003, 421 (6924)
:744-748

Cua, DJ
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Sherlock, J
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Chen, Y
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Murphy, CA
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Joyce, B
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Seymour, B
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Lucian, L
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

To, W
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Kwan, S
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Churakova, T
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Zurawski, S
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Wiekowski, M
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Lira, SA
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Gorman, D
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Kastelein, RA
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

Sedgwick, JD
论文数: 0 引用数: 0
h-index: 0
机构: DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA
[3]
How the gut senses its content
[J].
Didierlaurent, A
;
Sirard, JC
;
Kraehenbuhl, JP
;
Neutra, MR
.
CELLULAR MICROBIOLOGY,
2002, 4 (02)
:61-72

Didierlaurent, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

Sirard, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

Kraehenbuhl, JP
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland Univ Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

Neutra, MR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland
[4]
Gut flora in health and disease
[J].
Guarner, F
;
Malagelada, JR
.
LANCET,
2003, 361 (9356)
:512-519

Guarner, F
论文数: 0 引用数: 0
h-index: 0
机构:
Autonomous Univ Barcelona, Hosp Gen Valle Hebron, Digest Syst Res Unit, E-08035 Barcelona, Spain Autonomous Univ Barcelona, Hosp Gen Valle Hebron, Digest Syst Res Unit, E-08035 Barcelona, Spain

Malagelada, JR
论文数: 0 引用数: 0
h-index: 0
机构:
Autonomous Univ Barcelona, Hosp Gen Valle Hebron, Digest Syst Res Unit, E-08035 Barcelona, Spain Autonomous Univ Barcelona, Hosp Gen Valle Hebron, Digest Syst Res Unit, E-08035 Barcelona, Spain
[5]
Commensal host-bacterial relationships in the gut
[J].
Hooper, LV
;
Gordon, JI
.
SCIENCE,
2001, 292 (5519)
:1115-1118

Hooper, LV
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

Gordon, JI
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
[6]
Host recognition of bacterial muramyl dipeptide mediated through NOD2
[J].
Inohara, N
;
Ogura, Y
;
Fontalba, A
;
Gutierrez, O
;
Pons, F
;
Crespo, J
;
Fukase, K
;
Inamura, S
;
Kusumoto, S
;
Hashimoto, M
;
Foster, SJ
;
Moran, AP
;
Fernandez-Luna, JL
;
Nuñez, G
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2003, 278 (08)
:5509-5512

Inohara, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Ogura, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Fontalba, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Gutierrez, O
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Pons, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

论文数: 引用数:
h-index:
机构:

Fukase, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Inamura, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Kusumoto, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Hashimoto, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Foster, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Moran, AP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Fernandez-Luna, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Nuñez, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[7]
Timing, localization, and persistence of colonization by segmented filamentous bacteria in the neonatal mouse gut depend on immune status of mothers and pups
[J].
Jiang, HQ
;
Bos, NA
;
Cebra, JJ
.
INFECTION AND IMMUNITY,
2001, 69 (06)
:3611-3617

Jiang, HQ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

Bos, NA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

Cebra, JJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Philadelphia, PA 19104 USA Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
[8]
The bacterial flora in inflammatory bowel disease: Current insights in pathogenesis and the influence of antibiotics and probiotics
[J].
Linskens, RK
;
Huijsdens, XW
;
Savelkoul, PHM
;
Vandenbroucke-Grauls, CMJE
;
Meuwissen, SGM
.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY,
2001, 36
:29-40

Linskens, RK
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Acad Hosp, Dept Gastroenterol, Amsterdam, Netherlands

Huijsdens, XW
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Acad Hosp, Dept Gastroenterol, Amsterdam, Netherlands

Savelkoul, PHM
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Acad Hosp, Dept Gastroenterol, Amsterdam, Netherlands

Vandenbroucke-Grauls, CMJE
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Acad Hosp, Dept Gastroenterol, Amsterdam, Netherlands

Meuwissen, SGM
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Acad Hosp, Dept Gastroenterol, Amsterdam, Netherlands
[9]
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
[J].
Macpherson, AJ
;
Gatto, D
;
Sainsbury, E
;
Harriman, GR
;
Hengartner, H
;
Zinkernagel, RM
.
SCIENCE,
2000, 288 (5474)
:2222-+

Macpherson, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Spital Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Gatto, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Spital Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Sainsbury, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Spital Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Harriman, GR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Spital Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Hengartner, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Spital Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland

Zinkernagel, RM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Spital Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[10]
Regional variation of the αβ T cell repertoire in the colon of healthy individuals and patients with Crohn's disease
[J].
May, E
;
Lambert, C
;
Holtmeier, W
;
Hennemann, A
;
Zeitz, M
;
Duchmann, R
.
HUMAN IMMUNOLOGY,
2002, 63 (06)
:467-480

May, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA

Lambert, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA

Holtmeier, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA

Hennemann, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA

Zeitz, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA

Duchmann, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA