Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus

被引：56

作者：

Donnio, PY

Oliveira, DC

Faria, NA

Wilhelm, N

Le Coustumier, A

de Lencastre, H

机构：

[1] Ctr Hosp Univ, Lab Bacteriol Virol, F-35033 Rennes, France

[2] Univ Rennes 1, UPRES 1254 Microbiol, F-35043 Rennes, France

[3] Univ Nova Lisboa, Inst Tecnol Quim & Biol, P-2780156 Oeiras, Portugal

[4] Ctr Hosp, Biol Lab, F-46005 Cahors, France

[5] Rockefeller Univ, Microbiol Lab, New York, NY 10021 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 08期

关键词：

D O I：

10.1128/JCM.43.8.4191-4193.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS431::pUB110::IS431::dcs structure, present in some Staphylococcus cassette chromosome mec (SCCmec) types. The presence of SCCmec-associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCCmec from epidemic methicillin-resistant S. aureus. The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns.

引用

收藏

页码：4191 / 4193

页数：3

相关论文

共 26 条

[1] The changing epidemiology of Staphylococcus aureus? [J].

Chambers, HF .

EMERGING INFECTIOUS DISEASES, 2001, 7 (02) :178-182

[2] Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia:: A meta-analysis [J].

Cosgrove, SE ;

Sakoulas, G ;

Perencevich, EN ;

Schwaber, MJ ;

Karchmer, AW ;

Carmeli, Y .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (01) :53-59

[3] Changes in staphylococcal cassette chromosome type and antibiotic resistance profile in methicillin-resistant Staphylococcus aureus isolates from a French hospital over an 11 year period [J].

Donnio, PY ;

Preney, L ;

Gautier-Lerestif, AL ;

Avril, JL ;

Lafforgue, N .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (05) :808-813

[4] Nine-year surveillance of methicillin-resistant Staphylococcus aureus in a hospital suggests instability of mecA DNA region in an epidemic strain [J].

Donnio, PY ;

Louvet, L ;

Preney, L ;

Nicolas, D ;

Avril, JL ;

Desbordes, L .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (03) :1048-1052

[5] EXTRACHROMOSOMAL CONTROL OF METHICILLIN RESISTANCE AND TOXIN PRODUCTION IN STAPHYLOCOCCUS AUREUS [J].

DORNBUSCH, K ;

HALLANDER, HO ;

LOFQUIST, F .

JOURNAL OF BACTERIOLOGY, 1969, 98 (02) :351-+

[6] Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus [J].

Enright, MC ;

Day, NPJ ;

Davies, CE ;

Peacock, SJ ;

Spratt, BG .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (03) :1008-1015

[7] Comparative molecular analysis of community- or hospital-acquired methicillin-resistant Staphylococcus aureus [J].

Fey, PD ;

Saïd-Salim, B ;

Rupp, ME ;

Hinrichs, SH ;

Boxrud, DJ ;

Davis, CC ;

Kreiswirth, BN ;

Schlievert, PM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) :196-203

[8]

GRUBB WB, 1972, LANCET, V2, P1257

[9] The emergence and evolution of methicillin-resistant Staphylococcus aureus [J].

Hiramatsu, K ;

Cui, L ;

Kuroda, M ;

Ito, T .

TRENDS IN MICROBIOLOGY, 2001, 9 (10) :486-493

[10] New real-time PCR assay for rapid detection of methicillin-resistant Staphylococcus aureus directly from specimens containing a mixture of staphylococci [J].

Huletsky, A ;

Giroux, R ;

Rossbach, V ;

Gagnon, M ;

Vaillancourt, M ;

Bernier, M ;

Gagnon, F ;

Truchon, K ;

Bastien, M ;

Picard, FJ ;

van Belkum, A ;

Ouellette, M ;

Roy, PH ;

Bergeron, MG .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (05) :1875-1884