Novel α-amino amidine synthesis via scandium(III) triflate mediated 3CC Ugi condensation reaction

被引：56

作者：

Keung, W ^{[1
]}

Bakir, F ^{[1
]}

Patron, AP ^{[1
]}

Rogers, D ^{[1
]}

Priest, CD ^{[1
]}

Darmohusodo, V ^{[1
]}

机构：

[1] Senomyx Inc, Dept Chem, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 04期

关键词：

aminoamidines; hydantoin imides; imidopyrazines; lanthanides; multi-component Ugi;

D O I：

10.1016/j.tetlet.2003.11.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Amino amidines are made via a novel scandium(III) triflate catalyzed multi-component reaction involving aldehydes, amines. and isonitrile. The reaction can be automated and is amenable to library production. The chemistry of alpha-amino amidine described herein can be elaborated further for the synthesis of hydantoin imides and imidopyrazine derivatives. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：733 / 737

页数：5

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