Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages

被引：72

作者：

Li, Jun ^{[2
,3
]}

Liao, Chun-Ru ^{[2
,3
]}

Wei, Jun-Qi ^{[2
,3
]}

Chen, Li-Xia ^{[2
,3
]}

Zhao, Feng ^{[1
]}

Qiu, Feng ^{[2
,3
]}

机构：

[1] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

[3] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 18期

关键词：

Curcuma kwangsiensis; Diarylheptanoid; Inhibition of nitric oxide production; Macrophages; ZINGIBER-OFFICINALE; RHIZOMES; SESQUITERPENES; CONSTITUENTS; LONGA; COMOSA;

D O I：

10.1016/j.bmcl.2011.07.012

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Eleven diarylheptanoids (1-11) were isolated from rhizomes of Curcuma kwangsiensis, together with seven known compounds. Their structures were elucidated by 1D and 2D NMR, circular dichroism (CD), and accurate mass measurements. Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated. Compounds 1, 2, and 3 showed strong inhibitory activity on NO production with IC50 values of 3.13, 2.81 and 2.41 mu M, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5363 / 5369

页数：7

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