Childhood anaplastic large cell lymphoma has a high incidence of ALK gene rearrangement as determined by immunohistochemical staining and fluorescent in situ hybridisation:: a genetic and pathological correlation

被引：56

作者：

Perkins, SL

Pickering, D

Lowe, EJ

Zwick, D

Abromowitch, M

Davenport, G

Cairo, MS

Sanger, WG

机构：

[1] Univ Utah, Dept Pathol, Salt Lake City, UT 84132 USA

[2] ARUP Inst, Salt Lake City, UT 84132 USA

[3] Childrens Oncol Grp, Canc Grp, Arcadia, CA USA

[4] Univ Nebraska Med Ctr, Ctr Human Genet, Omaha, NE USA

[5] Childrens Hosp Kings Daughters, Div Pediat Hematol Oncol, Norfolk, VA USA

[6] Childrens Mercy Hosp, Dept Pathol, Kansas City, MO 64108 USA

[7] Univ Nebraska Med Ctr, Div Pediat Hematol Oncol, Omaha, NE 68198 USA

[8] Columbia Univ, Dept Pediat, Morgan Stanley Univ, New York, NY USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 131卷 / 05期

关键词：

anaplastic large cell lymphoma; ALK; fluorescent in situ hybridisation; immunochemistry; paediatric non-Hodgkin lymphoma;

D O I：

10.1111/j.1365-2141.2005.05808.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anaplastic large cell lymphoma (ALCL) comprises 10-15% of childhood non-Hodgkin lymphomas (NHL). Systemic ALCL is highly associated with anaplastic lymphoma kinase (ALK) gene translocations with over-expression of ALK protein. We studied ALK rearrangements using fluorescence in situ hybridisation (FISH) and ALK immunohistochemical staining in 43 paediatric systemic ALCLs. FISH (performed on 35 cases) identified a translocation in 29 cases (83%). Immunohistochemistry identified ALK overexpression in 42/43 cases (97%) with the single ALK-negative case demonstrating an ALK rearrangement by FISH, indicating 100% incidence of ALK translocations.

引用

页码：624 / 627

页数：4

共 11 条

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