Peripheral mononeuropathy affects hypothalamic and splenocyte beta-endorphin levels but not immune function in the rat

被引：8

作者：

Bianchi, M ^{[1
]}

Sotgiu, ML ^{[1
]}

Manfredi, B ^{[1
]}

Sacerdote, P ^{[1
]}

机构：

[1] CNR,IST NEUROSCI & BIOIMMAGINI,I-20129 MILAN,ITALY

来源：

BRAIN RESEARCH BULLETIN | 1996年 / 40卷 / 04期

关键词：

chronic constriction injury; hypothalamus; sciatic ligature; splenocyte; substance P; rat;

D O I：

10.1016/0361-9230(96)00051-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Beta-endorphin and substance P levels were measured in the hypothalamus of rats 14 days after chronic constriction injury of right sciatic nerve, Furthermore, beta-endorphin concentrations in splenocytes, phytoemoagglutinin-induced proliferation of splenocytes, and natural killer activity were assessed, We observed a significant increase of beta-endorphin and substance P hypothalamic levels, and a significant decrease of beta-endorphin concentrations in the immune cells, In contrast, the peripheral mononeuropathy did not affect the immune function. This study presents a picture of central and peripheral peptide changes consistent with a painful condition, but different from what previously observed in rats which underwent peripheral nerve deafferentation or stressful conditions.

引用

页码：269 / 272

页数：4

共 17 条

[1]

FURTHER EVIDENCE FOR PAIN-RELATED BEHAVIORS IN A MODEL OF UNILATERAL PERIPHERAL MONONEUROPATHY [J].