Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review) - Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

被引：254

作者：

Simpson, D. M. ^{[1
]}

Gracies, J. -M. ^{[2
]}

Graham, H. K.

Miyasaki, J. M. ^{[3
]}

Naumann, M. ^{[4
]}

Russman, B. ^{[5
]}

Simpson, L. L. ^{[6
]}

So, Y. ^{[7
]}

机构：

[1] Mt Sinai Med Ctr, Dept Neurol, New York, NY 10029 USA

[2] CHU Henri Mondor, Dept Rehabil Med, F-94010 Creteil, France

[3] Toronto Western Hosp, Toronto, ON, Canada

[4] Klinikum Augsburg, Dept Neurol, Augsburg, Germany

[5] Shriners Hosp Children, Portland, OR 97201 USA

[6] Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA

[7] Stanford Univ, Stanford, CA 94305 USA

来源：

NEUROLOGY | 2008年 / 70卷 / 19期

关键词：

D O I：

10.1212/01.wnl.0000311391.00944.c4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of adult and childhood spasticity. Methods: A literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and spasticity. Authors reviewed, abstracted, and classified articles based on American Academy of Neurology criteria (ClassI-IV). Results: The highest quality literature available for the respective indications was as follows: adult spasticity (14 Class I studies); spastic equinus and adductor spasticity in pediatric cerebral palsy (six Class I studies). Recommendations: Botulinum neurotoxin should be offered as a treatment option for the treatment of spasticity in adults and children (Level A).

引用

页码：1691 / 1698

页数：8

共 48 条

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