Low concentrations of ouabain increase cytosolic free calcium concentration in rat vascular smooth muscle cells

被引：26

作者：

Zhu, ZM ^{[1
]}

Tepel, M ^{[1
]}

Neusser, M ^{[1
]}

Zidek, W ^{[1
]}

机构：

[1] UNIV MUNSTER, MED POLIKLIN, D-48129 MUNSTER, GERMANY

来源：

CLINICAL SCIENCE | 1996年 / 90卷 / 01期

关键词：

calcium; ouabain; vascular smooth muscle;

D O I：

10.1042/cs0900009

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. Low ouabain concentrations in the nanomolar range significantly increased cytosolic free calcium concentration. 2. The ouabain-induced cytosolic free calcium concentration increase was due to transplasmamembrane calcium influx, which could be prevented in the absence of extracellular calcium or by addition of the calcium channel blocker nifedipine. 3. The amount of stored cellular Ca2+, as determined by the thapsigargin-induced cytosolic free calcium concentration increase, was also enhanced by 1 nmol/l ouabain. 4. It is concluded that low ouabain concentrations affect intracellular cytosolic free calcium concentration homoeostasis.

引用

页码：9 / 12

页数：4

共 24 条

[1] EXTRACELLULAR NA+ DEPENDENCY OF FREE CYTOSOLIC CA2+ REGULATION IN AORTIC VASCULAR SMOOTH-MUSCLE CELLS [J].