Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein

被引:158
作者
Schroeter, H
Williams, RJ
Matin, R
Iversen, L
Rice-Evans, CA
机构
[1] Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, Wolfson Ctr Age Related Dis, London SE1 9RT, England
[2] Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, Ctr Neurosci, London SE1 9RT, England
关键词
flavonoids; oxidized low-density lipoprotein; oxidative stress; neurodegeneration; LDL uptake; glutamate; free radicals;
D O I
10.1016/S0891-5849(00)00415-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oxidative stress is implicated in neuronal loss associated with neurodegeneration such as in Parkinson's disease, Alzheimer's disease and age-related cognitive decline. Recent reports indicate that the consumption of flavonoid-rich fruits partly reverses the age-related neuronal and cognitive decline. In this study, cultured striatal neurons were exposed to oxidized lipids in the form of low-density lipoprotein (oxLDL) as a model for the induction of oxidative injury, and the abilities of phenolic antioxidants, flavonoids and hydroxycinnamic acid derivatives, to attenuate this neuronal damage were examined. OxLDL was demonstrated to enter neuronal cells and to be capable of eliciting neurotoxicity in a dose- and time-dependent manner, inducing DNA fragmentation and cell lysis. Flavonoids exert protective effects, which appear to be related to specific structural characteristics, particularly relevant being those defining their reduction potentials and partition coefficients. In summary, these data suggest a possible role for flavonoids in reducing neurodegeneration associated with chronic disorders in which oxidative stress is implicated. (C) 2000 Elsevier Science Inc.
引用
收藏
页码:1222 / 1233
页数:12
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