The copper-mediated cross coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature:: Synthesis of aryloxyamines

被引：114

作者：

Petrassi, HM

Sharpless, KB

Kelly, JW

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 01期

关键词：

D O I：

10.1021/ol0003533

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel route to aryloxyamines via the copper mediated cross-coupling of N-hydroxyphthalimide and phenylboronic acids is reported. The reaction is mediated by selected copper(I) and (II) salts in the presence of pyridine and is tolerant of several functional groups on the phenylboronic acid. The phthalimide group is removed using hydrazine to afford the corresponding aryloxyamine.

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页码：139 / 142

页数：4

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