Fetal dopamine receptor characteristics assessed in utero

被引：4

作者：

Bartlett, Rachel M. ^{[1
]}

DeJesus, Onofre T. ^{[1
]}

Barnhart, Todd E. ^{[1
]}

Nickles, R. Jerome ^{[1
]}

Christian, Bradley T. ^{[1
]}

Graner, John L. ^{[1
]}

Holden, James E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Med Phys, Sch Med & Publ Hlth, Wisconsin Inst Med Res B1137, Madison, WI 53705 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 08期

关键词：

animal studies; brain development; dopamine; kinetic modeling; receptor imaging; GRAPHICAL ANALYSIS; PET DATA; NONHUMAN; PRIMATES;

D O I：

10.1038/jcbfm.2010.77

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Any tracer in fetal tissue comes from maternal arterial blood. Provided steady state is achieved and intermediate compartments are reversible, the Logan graphical methods should be applicable to the assessment of binding parameters in the fetal brain. Two pregnant rhesus macaques were studied with fallypride and the Logan method was used to assess dopamine receptor distribution volume ratios (DVRs) in both maternal and fetal striatum. The agreement between fetal striatal DVRs using maternal arterial blood and maternal and fetal cerebellum as input functions strongly supports our hypothesis that the conditions necessary for graphical analysis have been met. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1437-1440; doi: 10.1038/jcbfm.2010.77; published online 9 June 2010

引用

页码：1437 / 1440

页数：4

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