Enkephalins: Raman spectral analysis and comparison as function of pH 1-13

被引：13

作者：

Abdali, S

Refstrup, P

Nielsen, OF

Bohr, H

机构：

[1] Tech Univ Denmark, Dept Phys, Quantum Prot Ctr QUP, DK-2800 Kongens Lyngby, Denmark

[2] Univ Copenhagen, Inst Chem, DK-2100 Copenhagen Orsted, Denmark

来源：

BIOPOLYMERS | 2003年 / 72卷 / 05期

关键词：

enkephalin; Raman; molecular spectroscopy; pH effect;

D O I：

10.1002/bip.10404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Raman spectral studies are carried out on Leu- and Met-enkephalin as a function of the pH value in the range of 1-13. The molecules are dissolved in KCI solvent and the pH is controlled at each value. Spectral analyses reveal the dependence of the structural conformation on the pH, and a comparison of the two molecules is made in three frequency regions: the tyrosine Fermi doublet (850-830 cm(-1)), aromatic side chains (1650-1550 cm(-1)), and carboxylate (1430-1400 cm(-1)). All regions and frequencies are presented, discussed, and compared for the two molecules. (C) 2003 Wiley Periodicals, Inc.

引用

页码：318 / 328

页数：11

共 49 条

[1] Vibrational absorption spectra, DFT and SCC-DFTB conformational study and analysis of [Leu]enkephalin [J].