Risk of Clostridium difficile-associated disease among patients receiving proton-pump inhibitors in a Quebec medical intensive care unit

被引：49

作者：

Beaulieu, Mathieu

Williamson, David

Pichette, Gilbert

Lachaine, Jean

机构：

[1] Univ Montreal, Hop Sacre Coeur, Fac Pharm, Dept Microbiol, Montreal, PQ, Canada

[2] Univ Montreal, Hop Sacre Coeur, Fac Pharm, Dept Pharm, Montreal, PQ, Canada

来源：

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2007年 / 28卷 / 11期

关键词：

D O I：

10.1086/521664

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Our study was conducted to determine whether use of gastric acid suppressive agents increased the risk of Clostridium difficile-associated disease (CDAD) in a medical intensive care unit of one of the first hospitals to be threatened by the current CDAD epidemic in Quebec, Canada. Our findings suggest that efforts to determine risk factors for CDAD should focus on other areas, such as older age and antibiotic use.

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收藏

页码：1305 / 1307

页数：3

相关论文

共 11 条

[1] Moxifloxacin therapy as a risk factor for clostridium difficile-associated disease during an outbreak: Attempts to control a new epidemic strain [J].

Biller, Priscilla ;

Shank, Beth ;

Lind, Leah ;

Brennan, Meghan ;

Tkatch, Lisa ;

Killgore, George ;

Thompson, Angela ;

McDonald, L. Clifford .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2007, 28 (02) :198-201

[2]

Centers for Disease Control and Prevention, CLOSTR DIFF INF

[3] Project IMPACT: Results from a pilot validity study of a new observational database [J].

Cook, SF ;

Visscher, WA ;

Hobbs, CL ;

Williams, RL .

CRITICAL CARE MEDICINE, 2002, 30 (12) :2765-2770

[4] Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors:: cohort and case-control studies [J].

Dial, S ;

Alrasadi, K ;

Manoukian, C ;

Huang, A ;

Menzies, D .

CANADIAN MEDICAL ASSOCIATION JOURNAL, 2004, 171 (01) :33-38

[5] Hospitals battling outbreaks of C-difficile [J].

Eggertson, L ;

Sibbald, B .

CANADIAN MEDICAL ASSOCIATION JOURNAL, 2004, 171 (01) :19-21

[6] A hospital outbreak of diarrhea due to an emerging epidemic strain of Clostridium difficile [J].

Kazakova, Sophia V. ;

Ware, Kim ;

Baughman, Brittany ;

Bilukha, Oleg ;

Paradis, Anne ;

Sears, Stephen ;

Thompson, Angie ;

Jensen, Bette ;

Wiggs, Lois ;

Bessette, Jemelie ;

Martin, James ;

Clukey, Judy ;

Gensheimer, Kathleen ;

Killgore, George ;

McDonald, L. Clifford .

ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (22) :2518-2524

[7] Laboratory diagnosis of Clostridium difficile-associated diarrhea and colitis:: Usefulness of premier cytoclone A+B enzyme immunoassay for combined detection of stool toxins and toxigenic C-difficile strains [J].

Lozniewski, A ;

Rabaud, C ;

Dotto, E ;

Weber, M ;

Mory, F .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (05) :1996-1998

[8] A large outbreak of Clostridium Difficile -: Associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use [J].

Muto, CA ;

Pokrywka, M ;

Shutt, K ;

Mendelsohn, AB ;

Nouri, K ;

Posey, K ;

Roberts, T ;

Croyle, K ;

Krystofiak, S ;

Patel-Brown, S ;

Pasculle, AW ;

Paterson, DL ;

Saul, M .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2005, 26 (03) :273-280

[9] Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea:: A cohort study during an epidemic in Quebec [J].

Pépin, J ;

Saheb, N ;

Coulombe, MA ;

Alary, ME ;

Corriveau, MP ;

Authier, S ;

Leblanc, M ;

Rivard, G ;

Bettez, M ;

Primeau, V ;

Nguyen, M ;

Jacob, CE ;

Lanthier, L .

CLINICAL INFECTIOUS DISEASES, 2005, 41 (09) :1254-1260

[10] C-difficile inquest too narrow as "Quebec strain" goes international [J].

Pindera, Loreen .

CANADIAN MEDICAL ASSOCIATION JOURNAL, 2007, 176 (07) :915-916