Thermal optimisation of the Reimer-Tiemann reaction using thermochromic liquid crystals on a microfluidic reactor

被引：38

作者：

Iles, A

Fortt, R

de Mello, AJ

机构：

[1] ICYS, NIMS, Tsukuba, Ibaraki 3050044, Japan

[2] Cent Res Labs Ltd, Hayes UB3 1HH, Middx, England

[3] Univ London Imperial Coll Sci Technol & Med, London SW7 2AY, England

来源：

LAB ON A CHIP | 2005年 / 5卷 / 05期

关键词：

D O I：

10.1039/b419081e

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Microreactors incorporating thin film resistive heating elements for continuous flow organic synthesis are presented. Internal thermal conditions were monitored in real time using reflectance spectra of temperature sensitive thermochromic liquid crystals (TLC) in a collateral microfluidic network. To demonstrate the precise temperature control provided by this method, the thermal optimisation of the Reimer - Tiemann formylation of beta-naphthol was performed under hydrodynamic pumping regimes.

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页码：540 / 544

页数：5

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